Association of pancreatic fat content with type II diabetes mellitus
Association of pancreatic fat content with type II diabetes mellitus
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DOI：
10.1016/j.crad.2019.05.027
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发表时间：
2020-01-01
影响因子：
2.6
通讯作者：
Sandrasegaran, K.
中科院分区：
文献类型：
--
作者：
Nadarajah, C.;Fananapazir, G.;Sandrasegaran, K.
目的：确定胰腺局部脂肪含量与是否存在II型糖尿病（T2 DM）之间的相关性、局部胰腺脂肪定量在识别T2 DM风险患者中的价值以及胰腺脂肪含量是否与T2 DM的血糖控制相关。材料和方法：一项放射学数据库的回顾性调查确定了45例T2 DM患者和81例在磁共振成像（MRI）后0.6 - 3.7年发生糖尿病的“T2 DM风险”患者。在5年随访期间未发生糖尿病且无已知代谢综合征、肝脏或胰腺疾病的对照组也被确定。通过将感兴趣区域（ROI）放置在同相和异相化学位移MRI图像上来测量脂肪含量。多个临床参数，包括体重指数，胆固醇水平，血压，糖化血红蛋白（HbA 1c;在T2 DM组）covered.Results：有T2 DM和对照组之间的脂肪分数在胰头（p=0.043），身体（p=0.015），和尾部（p=0.001），但没有肝脏（p=0.107）的显着差异。在回归分析中，对照组和T2 DM“风险”组之间仅胰尾内的脂肪分数存在显著差异（p=0.007）。胰尾脂肪含量>10%预测4年内发生T2 DM的敏感性为45.5%，特异性为81.3%。胰腺脂肪含量与血糖控制无关。结论：胰腺尾部脂肪增加可识别T2 DM患者的风险。(C)2019年皇家放射科医师学院。由爱思唯尔有限公司出版。保留所有权利。
AIM: To determine the association between regional fat content in the pancreas and the presence or absence of type II diabetes mellitus (T2DM), the value of regional pancreatic fat quantification in identifying patients at risk of T2DM, and whether pancreatic fat content is associated with glycaemic control in T2DM.MATERIALS AND METHODS: A retrospective survey of a radiology database identified 45 patients with T2DM, and 81 "at risk for T2DM" patients who developed diabetes, between 0.6 and 3.7 years after magnetic resonance imaging (MRI). A control group who did not develop diabetes during a 5-year follow-up and without known metabolic syndrome, liver, or pancreatic diseases were also identified. Fat content was measured by placing regions of interest (ROIs) on in-phase and out-of-phase chemical shift MRI images. Multiple clinical parameters including body mass index, cholesterol levels, blood pressure, glycated haemoglobin (HbA1c; in T2DM group) were collected.RESULTS: There was a significant difference between the T2DM and control groups for fat fraction in the pancreatic head (p=0.043), body (p=0.015), and tail (p=0.001), but not liver (p=0.107). On regression analysis, only the fat fraction within the pancreatic tail was significantly different between control group and "at risk" for T2DM group (p=0.007). A pancreatic tail fat content of >10% had a sensitivity of 45.5% and specificity of 81.3% for predicting development of T2DM within 4 years. Pancreatic fat content was not associated with glycaemic control.CONCLUSIONS: Increased fat in the pancreatic tail may identify patients at risk for T2DM. (C) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.