THE ACTIVATION OF Ca 2+ -MOBILIZING RECEPTORS IN SALIVARY GLAND
THE ACTIVATION OF Ca 2+ -MOBILIZING RECEPTORS IN SALIVARY GLAND
复制标题
唾液腺中 Ca 2 动员受体的激活
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
S. Furuyama
中科院分区：
文献类型：
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作者：
H. Sugiya;S. Furuyama
在各种各样的细胞中，受激动剂刺激的表面膜上的Ca2+动员受体激活磷脂酶C。磷脂酶C的激活似乎是由鸟嘌呤核苷酸依赖的调节蛋白介导的，并导致磷脂酰肌醇4,5-二磷酸的水解。这种水解导致产生肌醇1,4,5-三磷酸[(1,4,5)IP3]和二酰基甘油（DG）。（1,4,5）IP3刺激钙离子从细胞内池释放，DG激活钙磷脂依赖性蛋白激酶。因此这些分子被认为是第二信使。本文就目前腮腺唾液腺磷酸肌肽代谢与钙动员关系的研究进展作一综述。
In a wide variety of cells, Ca2+-mobilizing receptors on the surface membrane stimulated by agonists activate phospholipase C. The activation of phospholipase C appears to be mediated by guanine nucleotide-dependent regulatory protein(s), and results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate. This hydrolysis leads to the production of inositol 1,4,5-trisphosphate [(l,4,5)IP3] and diacylglycerol (DG). (l,4,5)IP3 stimulates the Ca“ release from an intracellular pool and DG activates calcium-phospholipid-dependent protein kinase. Therefore these molecules are considered second messengers. The purpose of this review is to summarize some current ideas on the relationship between phosphoinositide metabolism and Ca“ mobilization in parotid salivary gland.