Arterial Venous Differentiation for Vascular Bioengineering.
Arterial Venous Differentiation for Vascular Bioengineering.
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DOI：
10.1146/annurev-bioeng-062117-121231
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发表时间：
2018-06-04
影响因子：
9.7
通讯作者：
中科院分区：
文献类型：
--
作者：
动脉和静脉的发育过程是根本不同的，导致在解剖、结构和功能以及分子图谱上的明显差异。了解遗传和表观遗传途径之间的复杂相互作用，以及协调动脉静脉分化的细胞外和生物力学信号，不仅对于理解动脉和静脉的血管疾病至关重要，而且对血管组织工程策略也很有价值。最近的研究表明，某些转录因子不仅在发育过程中控制动脉静脉的分化，而且在成人血管功能和疾病过程中发挥关键作用。该综述总结了信号通路和关键转录因子对动脉和静脉的规范是重要的。我们专注于那些与动脉和静脉的结构和功能有直接关系的信号，并对血管疾病过程和组织工程应用具有影响。
The development processes of arteries and veins are fundamentally different, leading to distinct differences in anatomy, structure, and function as well as molecular profiles. Understanding the complex interaction between genetic and epigenetic pathways, as well as extracellular and biomechanical signals that orchestrate arterial venous differentiation, is not only critical for the understanding of vascular diseases of arteries and veins but also valuable for vascular tissue engineering strategies. Recent research has suggested that certain transcriptional factors not only control arterial venous differentiation during development but also play a critical role in adult vessel function and disease processes. This review summarizes the signaling pathways and critical transcription factors that are important for arterial versus venous specification. We focus on those signals that have a direct relation to the structure and function of arteries and veins, and have implications for vascular disease processes and tissue engineering applications.
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