Leukotrienes in gynaecology: the hypothetical value of anti-leukotriene therapy in dysmenorrhoea and endometriosis
Leukotrienes in gynaecology: the hypothetical value of anti-leukotriene therapy in dysmenorrhoea and endometriosis
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DOI：
10.1093/humupd/6.2.200
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发表时间：
2000-03-01
影响因子：
13.3
通讯作者：
Konje, JC
中科院分区：
文献类型：
--
作者：
Abu, JI;Konje, JC
脂氧合酶产物（白三烯）已在包括人类在内的许多哺乳动物组织中得到证实。它们广泛分布于肺、肺、子宫、肾、皮肤、心脏和肝脏。它们作为炎症介质的作用使它们成为治疗目标。大量白三烯已被证实存在于对抗前列腺素治疗无效的原发性痛经妇女的子宫内膜中。此外，在子宫内膜异位症中，可启动白三烯生物合成级联反应的细胞因子已被证实升高。据估计，10-30%的痛经患者对前列腺素合成酶抑制剂无效。大约40%的成年女性月经疼痛，其中10%的女性每月有1-3天无法工作，大约10%的15-45岁的女性患有子宫内膜异位症，这是导致不孕症的一个重要原因，白三烯受体拮抗剂最近在英国被许可用于治疗哮喘。在这篇综述中，我们提出了这些产品在原发性痛经治疗中的潜在应用（特别是在使用PG合成酶抑制剂的传统治疗无效的患者中），也可能在子宫内膜异位症的病例中。
The lipoxygenase products (leukotrienes) have been demonstrated in many mammalian tissues including humans. They are widely distributed in the lungs, got, uterus, kidneys, skin, heart and the liver. Their roles as mediators of inflammation have made them therapeutic targets. Significant amounts of leukotrienes have been demonstrated in the endometrium of women with primary dysmenorrhoea who do not respond to treatment with anti-prostaglandins, Also, in endometriosis, cytokines, which can initiate the cascade for the biosynthesis of leukotrienes, have been shown to be elevated, It is estimated that 10-30% of patients with painful periods fail to respond to prostaglandin (PG) synthetase inhibitors, Of adult females similar to 40% have painful menstruation and 10% of these are incapacitated for 1-3 days per month, and similar to 10% of women aged between 15-45 years suffer from endometriosis, which is a significant cause of infertility, Leukotriene receptor antagonists have recently been licensed for the treatment of asthma in the UK. In this review, we present the case for the potential use of these products in the management of primary dysmenorrhoea (especially in patients who are not responding to the traditional treatment using PG synthetase inhibitors) and possibly also in cases of endometriosis.