High intensity aerobic exercise improves bimanual coordination of grasping forces in Parkinson's disease.
High intensity aerobic exercise improves bimanual coordination of grasping forces in Parkinson's disease.
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高强度有氧运动改善帕金森氏症患者双手抓握力的协调性。
DOI：
10.1016/j.parkreldis.2021.04.005
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发表时间：
2021-06
影响因子：
4.1
通讯作者：
Alberts JL
中科院分区：
文献类型：
--
作者：
Jansen AE;Koop MM;Rosenfeldt AB;Alberts JL
帕金森氏病（PD）会破坏抓握力的控制和协调，这可能是由于基底神经节回路中断和辅助运动区（SMA）内的活动减少。高强度有氧运动已被证明可以增强基底神经节核和皮质区域（包括SMA）之间的连接。本研究的目的是确定高强度下肢运动对运动控制模式的影响。PD参与者在强迫或自愿运动（FE或VE）模式下完成了8周的高强度有氧运动。在一个功能性双手灵巧性任务中，对每个肢体的抓握力进行了量化。在基线、治疗结束（EOT）和运动停止后8周（EOT+8），在停用抗帕金森病药物时收集数据。8周的高强度运动使FE和VE组的MDS-MRS运动III临床评分提高了4分以上（约15%）。两组完成任务的时间也减少了近30%。抓握力的控制和协调，力启动的快速性，以及抓握力和负载力的速率在运动后表现出显着的改善。一般来说，生物力学结果的改善在运动停止后持续。通过强迫或自愿模式实现的高强度有氧运动可改善PD症状和双手灵巧性。运动停止后上肢运动控制的持续改善表明高强度运动可增强CNS功能，并表明运动可能是改变PD进展的候选者。
Parkinson’s disease (PD) disrupts the control and coordination of grasping forces, likely due to a disruption in basal ganglia circuitry and diminished activity within the supplementary motor area (SMA). High intensity aerobic exercise has been shown to enhance connectivity between basal ganglia nuclei and cortical areas, including the SMA. The aim of this project was to determine the effects of high intensity lower extremity exercise on motor control patterns underlying a manual dexterity task. PD participants completed eight weeks of high intensity aerobic exercise under forced or voluntary exercise (FE or VE) modalities. Grasping forces for each limb were quantified during a functional bimanual dexterity task. Data were collected while OFF antiparkinsonian medication at baseline, end of treatment (EOT), and eight weeks after exercise cessation (EOT+8). Eight weeks of high intensity exercise improved MDS-UPDRS Motor III clinical ratings by more than 4 points (~15%) for the FE and VE groups. Time to complete the task decreased nearly 30% across both groups as well. The control and coordination of grasping forces, simultaneity of force initiation, and rate of grip and load force exhibited significant improvements following exercise. In general, improvements in biomechanical outcomes were sustained following exercise cessation. High intensity aerobic exercise, achieved via a forced or voluntary mode, improved PD symptoms and bimanual dexterity. Sustained improvement of upper extremity motor control following exercise cessation indicates high intensity exercise enhances CNS functioning and suggests exercise may be a candidate for altering PD progression.
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影响因子：
4.2
作者：
Ridgel, Angela L.;Vitek, Jerrold L.;Alberts, Jay L.
通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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