Stimulation of creatine kinase BB activity by 1 alpha,25-dihydroxycholecalciferol and 24R,25-dihydroxycholecalciferol in rat tissues.
Stimulation of creatine kinase BB activity by 1 alpha,25-dihydroxycholecalciferol and 24R,25-dihydroxycholecalciferol in rat tissues.
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大鼠组织中 1 α,25-二羟基胆钙化醇和 24R,25-二羟基胆钙化醇对肌酸激酶 BB 活性的刺激。
DOI：
10.1042/bj2191037
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
A. Kaye
中科院分区：
文献类型：
--
作者：
D. Sömjen;Y. Weisman;I. Binderman;A. Kaye
维生素D代谢物刺激维生素D缺乏大鼠器官中肌酸激酶BB活性。在长骨骨骺，肌酸激酶BB活性增加2.6倍后24小时注射24 R，25-二羟基胆钙化醇，但不是1 α，25-二羟基胆钙化醇。相反，1 α，25-二羟基胆钙化醇，而不是24 R，25-二羟基胆钙化醇，增加骨干和肾脏中的肌酸激酶BB活性。这两种代谢产物均不影响十二指肠粘膜中的肌酸激酶活性。
Vitamin D metabolites stimulate creatine kinase BB activity in organs of vitamin D-deficient rats. In epiphyses of long bones, creatine kinase BB activity increases 2.6-fold 24 h after injection of 24R,25-dihydroxycholecalciferol but not of 1 alpha,25-dihydroxycholecalciferol. Contrariwise, 1 alpha,25-dihydroxycholecalciferol, but not 24R,25-dihydroxycholecalciferol, increases creatine kinase BB activity in diaphyses and in kidney. Neither metabolite affects creatine kinase activity in duodenal mucosa.