Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat
Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat
复制标题
DOI：
10.1016/j.canlet.2005.01.019
复制
发表时间：
2006-01-08
期刊：
影响因子：
9.7
通讯作者：
Singh, NP
中科院分区：
文献类型：
--
作者：
Lai, H;Singh, NP
青蒿素是一种从甜蒿中分离出来的化合物，此前已被证明对体外癌细胞具有选择性毒性。在本实验中，我们研究了青蒿素预防大鼠患乳腺癌的潜力，这些大鼠接受单剂量（50 mg/kg）7,12-二甲基苯并[a]蒽（DMBA）的口服剂量（DMBA），已知会诱发多种乳腺肿瘤。从DMBA治疗后的第二天开始，一组大鼠被提供含有0.02%青蒿素的粉状大鼠饲料，而对照组则被提供普通粉状食物。在 40 周的时间里，对两组大鼠的乳腺肿瘤进行监测。在监测期间，口服青蒿素显着延缓（P < .002）并在一些动物中预防（青蒿素喂养组的 57% 与对照组的 96% 发生肿瘤，P < .01）乳腺癌的发生。此外，与对照组相比，青蒿素喂养大鼠的乳腺肿瘤明显较少（P < .002）且尺寸更小（P < .05）。由于青蒿素是一种相对安全的化合物，即使在高口服剂量下也不会引起已知的副作用，因此目前的数据表明青蒿素可能是一种有效的癌症化学预防剂。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Artemisinin, a compound isolated from the sweet wormwood Artemisia annua L., has previously been shown to have selective toxicity towards cancer cells in vitro. In the present experiment, we studied the potential of artemisinin to prevent breast cancer development in rats treated with a single oral dose (50 mg/kg) of 7,12-dimethylbenz[a]anthracene (DMBA), known to induce multiple breast tumors. Starting from the day immediately after DMBA treatment, one group of rats was provided with a powdered rat-chow containing 0.02% artemisinin, whereas a control group was provided with plain powdered food. For 40 weeks, both groups of rats were monitored for breast tumors. Oral artemisinin significantly delayed (P < .002) and in some animals prevented (57% of artemisinin-fed versus 96% of the controls developed tumors, P < .01) breast cancer development in the monitoring period. In addition, breast tumors in artemisinin-fed rats were significantly fewer (P < .002) and smaller in size (P < .05) when compared with controls. Since artemisinin is a relatively safe compound that causes no known side effects even at high oral doses, the present data indicate that artemisinin may be a potent cancer-chemoprevention agent. (c) 2005 Elsevier Ireland Ltd. All rights reserved.