Epithelial-mesenchymal Transition and Cell Invasion.
Epithelial-mesenchymal Transition and Cell Invasion.
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DOI：
10.5487/tr.2010.26.4.245
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发表时间：
2010-12
影响因子：
2.3
通讯作者：
Moon A
中科院分区：
文献类型：
--
作者：
Son H;Moon A
上皮-间充质转化（epithelial -mesenchymal transition， EMT）是上皮细胞获得侵袭性间充质细胞特性的复杂过程。EMT与癌症的进展和转移以及发育过程中许多组织和器官的形成有关。上皮细胞在EMT过程中会失去细胞间的粘附结构和极性，并重新排列细胞骨架。几种致癌途径，如转化生长因子(TGF) -β、Wnt和Notch信号通路，已被证明可诱导EMT。这些途径激活了转录因子，包括Snail， Slug和ZEB家族，这些转录因子作为E-cadherin的转录抑制因子，从而使上皮细胞运动并抵抗凋亡。越来越多的证据表明，EMT与细胞侵袭和肿瘤进展有关。在这篇综述中，我们总结了EMT的特征、导致EMT的途径以及EMT在细胞侵袭中的作用。本综述涉及三个主题：(1)EMT的定义，(2)导致EMT的信号通路，(3)EMT在细胞侵袭中的作用。了解EMT在细胞侵袭中的作用将为制定策略开发抗转移治疗提供有价值的信息，这些治疗可以调节EMT介导的恶性细胞过程。
Epithelial-mesenchymal transition (EMT) is a complex process in which epithelial cells acquire the characteristics of invasive mesenchymal cells. EMT has been implicated in cancer progression and metastasis as well as the formation of many tissues and organs during development. Epithelial cells undergoing EMT lose cell-cell adhesion structures and polarity, and rearrange their cytoskeletons. Several oncogenic pathways such as transforming growth factor (TGF) -β, Wnt, and Notch signaling pathways, have been shown to induce EMT. These pathways have activated transcription factors including Snail, Slug, and the ZEB family which work as transcriptional repressors of E-cadherin, thereby making epithelial cells motile and resistant to apoptosis. Mounting evidence shows that EMT is associated with cell invasion and tumor progression.In this review, we summarize the characteristic features of EMT, pathways leading to EMT, and the role of EMT in cell invasion. Three topics are addressed in this review: (1) Definition of EMT, (2) Signaling pathways leading to EMT, (3) Role of EMT in cell invasion. Understanding the role of EMT in cell invasion will provide valuable information for establishing strategies to develop anti-metastatic therapeutics which modulate malignant cellular processes mediated by EMT.