The role of senescent T cells in immunopathology.
The role of senescent T cells in immunopathology.
复制标题
衰老T细胞在免疫病理学中的作用。
DOI：
10.1111/acel.13272
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发表时间：
2020-12
期刊：
影响因子：
7.8
通讯作者：
Akbar AN
中科院分区：
文献类型：
--
作者：
Covre LP;De Maeyer RPH;Gomes DCO;Akbar AN
不同器官组织和免疫系统中衰老的发展通常是相互独立的，尽管在衰老过程中，两个细胞系统中的衰老是同时发展的。衰老的 T 细胞具有高度炎症性，会分泌细胞毒性介质，并表达绕过其抗原特异性的自然杀伤细胞受体 (NKR)。相反，它们识别由组织中不同细胞类型的炎症或感染诱导的应激配体。在本文中，我们讨论有关 T 细胞衰老的数据、其调控方式以及衰老 T 细胞新功能属性的证据。我们讨论了衰老 T 细胞和衰老非淋巴细胞之间的相互作用循环，并得出结论：在严重炎症的情况下，衰老细胞可能会损害健康组织。虽然我们强调的衰老细胞诱导免疫病理学的例子是皮肤利什曼病，但这种器官损伤的情况可能适用于其他感染，包括 COVID-19 和类风湿性关节炎，其中衰老、炎症和衰老细胞都是同一个方程式的一部分。衰老发生在组织和免疫系统中，但人们对这之间的相互作用知之甚少。衰老 T 细胞具有促炎性，表达可独立于 TCR 发挥作用的 NK 受体，并且具有高度细胞毒性。它们识别发炎或感染组织中的细胞表达的应激配体或细胞衰老的结果。在这里，我们讨论衰老 T 细胞如何通过与衰老基质细胞相互作用，在感染环境中加剧组织损伤。我们重点关注皮肤利什曼病作为这种情况的模型，但表明这种情况也发生在其他感染（例如 COVID-19）以及自身免疫性疾病（例如类风湿性关节炎）中。
The development of senescence in tissues of different organs and in the immune system are usually investigated independently of each other although during ageing, senescence in both cellular systems develop concurrently. Senescent T cells are highly inflammatory and secrete cytotoxic mediators and express natural killer cells receptors (NKR) that bypass their antigen specificity. Instead they recognize stress ligands that are induced by inflammation or infection of different cell types in tissues. In this article we discuss data on T cell senescence, how it is regulated and evidence for novel functional attributes of senescent T cells. We discuss an interactive loop between senescent T cells and senescent non‐lymphoid cells and conclude that in situations of intense inflammation, senescent cells may damage healthy tissue. While the example for immunopathology induced by senescent cells that we highlight is cutaneous leishmaniasis, this situation of organ damage may apply to other infections, including COVID‐19 and also rheumatoid arthritis, where ageing, inflammation and senescent cells are all part of the same equation. Senescence occurs in tissues as well as in the immune system but the interaction between this is poorly understood. Senescent T cells are pro‐inflammatory, express NK receptors that can act independent of the TCR, and are highly cytotoxic. They recognise stress ligands expressed by cells in inflamed or infected tissues or as a consequence of cellular senescence. Here, we discuss how senescent T cells might contribute to exacerbated tissue damage in infectous contexts by interacting with senescent stromal cells. We focus on cutaneous leishmaniasis as a model for this but suggest that this occurs in other infections such as COVID‐19 and indeed autoimmune diseases such as rheumatoid arthritis.
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影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
6.5
作者：
Da-Cruz, Alda M.;Oliveira-Neto, Manoel P.;Coutinho, Sergio G.
通讯作者：
Coutinho, Sergio G.
影响因子：
18.2
作者：
Campisi J
通讯作者：
Campisi J
DOI：
10.1084/jem.178.2.427
发表时间：
1993-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Akbar AN;Borthwick N;Salmon M;Gombert W;Bofill M;Shamsadeen N;Pilling D;Pett S;Grundy JE;Janossy G
通讯作者：
Janossy G