Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study
Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study
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DOI：
10.1136/thx.2003.008730
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发表时间：
2004-05-01
期刊：
影响因子：
10
通讯作者：
Vidal, R
中科院分区：
文献类型：
--
作者：
Miravitlles, M;Ferrer, M;Vidal, R
背景：一项研究旨在评估慢性阻塞性肺疾病 (COPD) 患者的病情加重及其对健康相关生活质量 (HRQL) 的影响。方法：对 336 名平均 (SD) 年龄为 66 (8.2) 岁且平均 (SD) 1 秒用力呼气量 (FEV1) 33 (8)% 预测的 COPD 患者进行了 2 年随访研究。每 6 个月进行一次肺活量测试、有关 COPD 恶化的问题以及 HRQL 测量（圣乔治呼吸问卷 (SGRQ) 和 SF-12 健康调查）。 结果：总共记录了 1015 次急性加重，103 名 (30.7%) 患者在研究期间至少需要入院一次。调整基线特征和评估季节后，频繁发作对中度 COPD 患者的 HRQL 产生负面影响（FEV1 预计为 35 - 50%）；随访期间，发作次数大于或等于 3 次的中度患者的 SGRQ 总分变化几乎每年比发作次数为 3 次的患者高（差）2 分（p = 0.042）。对于患有严重慢性阻塞性肺病（FEV1
Background: A study was undertaken to evaluate exacerbations and their impact on the health related quality of life ( HRQL) of patients with chronic obstructive pulmonary disease ( COPD).Methods: A 2 year follow up study was performed in 336 patients with COPD of mean (SD) age 66 (8.2) years and mean (SD) forced expiratory volume in 1 second (FEV1) 33 (8)% predicted. Spirometric tests, questions regarding exacerbations of COPD, and HRQL measurements (St George's Respiratory Questionnaire (SGRQ) and SF-12 Health Survey) were conducted at 6 month intervals.Results: A total of 1015 exacerbations were recorded, and 103 (30.7%) patients required at least one hospital admission during the study. After adjustment for baseline characteristics and season of assessment, frequent exacerbations had a negative effect on HRQL in patients with moderate COPD ( FEV1 35 - 50% predicted); the change in SGRQ total score of moderate patients with greater than or equal to 3 exacerbations was almost two points per year greater ( worse) than those with,3 exacerbations during the follow up (p = 0.042). For patients with severe COPD (FEV1