Robustness of networked systems to unintended interactions with application to engineered genetic circuits
Robustness of networked systems to unintended interactions with application to engineered genetic circuits
复制标题
网络系统对意外相互作用的鲁棒性与工程遗传电路的应用
DOI：
10.1109/tcns.2021.3078144
复制
发表时间：
2021
影响因子：
4.2
通讯作者：
Del Vecchio, Domitilla
中科院分区：
文献类型：
--
作者：
Qian, Yili;Del Vecchio, Domitilla
一个网络化的动态系统是由多个子系统通过预定的相互作用相互连接而成的。然而，在许多工程应用中，一个子系统也可以通过“非预期”的交互影响其他子系统，从而显著改变预期网络的行为。虽然非预期的相互作用可以建模为干扰输入的子系统，这些干扰依赖于网络的状态。因此，每个子系统的干扰衰减特性不足以确保网络对非预期的相互作用是鲁棒的。在这里，我们提供了子系统动态和交互映射的条件，这样网络对非预期的交互是鲁棒的。这些条件要求每个子系统渐近衰减恒定的外部干扰，是单调或“近单调”，非预期的相互作用是单调的，并且规定的相互作用不包含反馈回路。我们应用这一结果来指导由反馈调节子系统组成的资源有限的遗传电路的设计。
A networked dynamical system is composed of subsystems interconnected via prescribed interactions. In many engineering applications, however, one subsystem can also affect others via “unintended” interactions that can significantly change the intended network's behavior. Although unintended interactions can be modeled as disturbance inputs to the subsystems, these disturbances depend on the network's states. Thus, a disturbance attenuation property of each subsystem is insufficient to ensure that the network is robust to unintended interactions. Here, we provide conditions on subsystem dynamics and interaction maps, such that a network is robust to unintended interactions. These conditions require that each subsystem asymptotically attenuates constant external disturbances, is monotone or “near-monotone,” the unintended interactions are monotone, and the prescribed interactions do not contain feedback loops. We apply this result to guide the design of resource-limited genetic circuits composed of feedback-regulated subsystems.