Chronic effects of inflammation on tauopathies
Chronic effects of inflammation on tauopathies
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DOI：
10.1016/s1474-4422(23)00116-3
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发表时间：
2023-04-13
期刊：
影响因子：
48
通讯作者：
Duff, Karen
中科院分区：
文献类型：
--
作者：
Langworth-Green, Connor;Patel, Saisha;Duff, Karen
tau蛋白病是一组异质性神经退行性疾病，其特征是微管相关蛋白tau蛋白聚集成神经元和神经胶质细胞内的丝状包涵体。阿尔茨海默病是最常见的 tau 蛋白病。尽管多年来进行了大量的研究工作，但针对这些疾病开发疾病缓解干预措施仍然非常具有挑战性。人们越来越认识到慢性炎症在阿尔茨海默病发病机制中所起的有害作用。然而，这主要归因于β淀粉样蛋白的积累，从而导致慢性炎症对tau蛋白病理学和神经原纤维缠结相关通路的影响被大大忽视。 Tau 病理学可以独立地继发于一系列与炎症过程相关的触发因素，包括感染、重复性轻度创伤性脑损伤、癫痫发作和自身免疫性疾病。更好地了解炎症对 tau蛋白病发生和进展的慢性影响可能有助于为临床应用建立有效的免疫调节疾病缓解干预措施开辟道路。
Tauopathies are a heterogeneous group of neurodegenerative disorders that are characterised by the aggregation of the microtubule-associated protein tau into filamentous inclusions within neurons and glia. Alzheimer's disease is the most prevalent tauopathy. Despite years of intense research efforts, developing disease-modifying interventions for these disorders has been very challenging. The detrimental role that chronic inflammation plays in the pathogenesis of Alzheimer's disease is increasingly recognised; however, it is largely ascribed to the accumulation of amyloid beta, leaving the effect of chronic inflammation on tau pathology and neurofibrillary tangle-related pathways greatly overlooked. Tau pathology can independently arise secondary to a range of triggers that are each associated with inflammatory processes, including infection, repetitive mild traumatic brain injury, seizure activity, and autoimmune disease. A greater understanding of the chronic effects of inflammation on the development and progression of tauopathies could help forge a path for the establishment of effective immunomodulatory diseasemodifying interventions for clinical use.