Vitamin D and atherosclerosis
Vitamin D and atherosclerosis
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DOI：
10.5937/bii2101099l
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
V. Lazić;B. Mijovic;M. Maksimovic;Olivera Rašević;Maida Mulić;Maja Vuković
中科院分区：
文献类型：
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作者：
V. Lazić;B. Mijovic;M. Maksimovic;Olivera Rašević;Maida Mulić;Maja Vuković
心血管疾病在全球死亡率中排名第一，占31%。根据世界卫生组织的建议，基本的预防措施是改变饮食、体育活动、烟草和酒精消费方面的危险生活方式。维生素D以前被认为是钙和磷比例的调节剂，骨重建或骨骼病理生理学的主要控制器。然而，维生素D在临床和流行病学研究中因其对降低心血管疾病风险的可能影响而受到极大关注。除其他外，维生素D缺乏与内皮功能障碍的风险增加有关。尽管维生素D缺乏已被确定为心血管疾病的风险标志物，但维生素D在内皮功能障碍至心血管疾病的路径上的作用机制尚未完全揭示。这部分维生素D活性的研究结果对于降低心血管疾病的发病率和死亡率具有重要意义。
Cardiovascular diseases rank first on the mortality list globally or 31%. The basic measure of prevention in accordance with the recommendations of the World Health Organization is a change in risk lifestyle in terms of diet, physical activity, tobacco and alcohol consumption. Vitamin D was previously recognized as a regulator of calcium and phosphorus ratio, bone remodeling or the main controller of skeletal pathophysiology. However, vitamin D enjoys great interest in clinical and epidemiological research in terms of its possible impact on reducing the risk of cardiovascular diseases. Among other things, vitamin D deficiency is associated with an increased risk of endothelial dysfunction. Although the deficiency has been identified as a risk marker for cardiovascular diseases, the mechanism of action of vitamin D on the path from endothelial dysfunction to cardiovascular diseases has not been fully revealed. The findings in this segment of activity of vitamin D would be significant in terms of reducing morbidity and mortality from cardiovascular diseases.