The Prevalence and Risk Factors of Undiagnosed Depression and Anxiety Disorders Among Patients With Inflammatory Bowel Disease
The Prevalence and Risk Factors of Undiagnosed Depression and Anxiety Disorders Among Patients With Inflammatory Bowel Disease
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DOI：
10.1093/ibd/izz045
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发表时间：
2019-10-01
影响因子：
4.9
通讯作者：
Marriott, James
中科院分区：
文献类型：
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作者：
Lewis, Kylee;Marrie, Ruth Ann;Marriott, James
背景：炎症性肠病（IBD）与抑郁和焦虑障碍共病的高患病率相关。有相当比例的IBD患者合并精神疾病仍未得到诊断和治疗，但与诊断相关的因素尚不清楚。我们评估了未确诊的抑郁症和焦虑症的患病率在IBD队列，沿着相关的人口统计学和临床characteristics.Methods：我们获得的数据从一个队列研究的精神并发症的免疫介导的疾病，包括IBD的登记访问。每位参与者都接受了DSM-IV-TR轴I障碍（SCID）的结构化临床访谈，以确定符合抑郁或焦虑诊断终身标准的参与者。这些与SCID为基础的诊断被归类为诊断或未诊断的基础上参与者报告的医生diagnosis.Results：242名合格的参与者，97（40.1%）符合SCID标准的抑郁症，74（30.6%）符合标准的焦虑。三分之一的抑郁症患者和三分之二的焦虑症患者未被诊断出来。男性更可能患有未确诊的抑郁症（比值比[OR]，3.36; 95%置信区间[CI]，1.28-8.85）。非白人参与者不太可能有一个未确诊的焦虑症（OR，0.17; 95%CI，0.042-0.72）。结论：我们的研究结果强调了IBD患者的抑郁和焦虑筛查的重要性，特别要注意那些男性和教育水平较低。
Background: Inflammatory bowel disease (IBD) is associated with a high prevalence of comorbid depressive and anxiety disorders. A significant proportion of IBD patients with comorbid psychiatric disorders remain undiagnosed and untreated, but factors associated with diagnosis are unknown. We evaluated the prevalence of undiagnosed depression and anxiety in an IBD cohort, along with the associated demographic and clinical characteristics.Methods: We obtained data from the enrollment visit of a cohort study of psychiatric comorbidity in immune-mediated diseases including IBD. Each participant underwent a Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID) to identify participants who met lifetime criteria for a diagnosis of depression or anxiety. Those with a SCID-based diagnosis were classified as diagnosed or undiagnosed based on participant report of a physician diagnosis.Results: Of 242 eligible participants, 97 (40.1%) met SCID criteria for depression, and 74 (30.6%) met criteria for anxiety. One-third of participants with depression and two-thirds with anxiety were undiagnosed. Males were more likely to have an undiagnosed depressive disorder (odds ratio [OR], 3.36; 95% confidence interval [CI], 1.28-8.85). Nonwhite participants were less likely to have an undiagnosed anxiety disorder (OR, 0.17; 95% CI, 0.042-0.72).Conclusion: Our findings highlight the importance of screening for depression and anxiety in patients with IBD, with particular attention to those of male sex and with a lower education level.