Structure-activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
Structure-activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
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DOI：
10.1016/j.bmc.2006.02.032
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发表时间：
2006-07-01
影响因子：
3.5
通讯作者：
Ojika, Makoto
中科院分区：
文献类型：
--
作者：
Han, Chunguang;Qi, Jianhua;Ojika, Makoto
从冲绳蓝海星Linckia laevigata中分离得到6个新的甾体苷类化合物linckosides F-K及其代谢产物，作为神经生长因子（NGF）的模拟物或增强剂。通过光谱法和化学衍生化方法确定了它们的结构和立体化学。结构-活性关系表明，在侧链上由戊糖修饰的碳分支和在糖苷配基的C-3处的2 '-O-甲基吡喃木糖对于神经元活性都是重要的。(c)2006爱思唯尔有限公司保留所有权利。
Six new steroid glycosides, linckosides F-K, and a related metabolite were isolated from the Okinawan blue starfish Linckia laevigata as mimics or enhancers of nerve growth factor (NGF). Their structures and stereochemistry were elucidated by spectroscopic methods and chemical derivatization. Structure-activity relationships suggest that both a carbon branch modified by a pentose at the side chain and 2'-O-methylxylopyranose at C-3 of the aglycon are important for neuritogenic activity. (c) 2006 Elsevier Ltd. All rights reserved.