A pilot treatment study for mild traumatic brain injury: Neuroimaging changes detected by MEG after low-intensity pulse-based transcranial electrical stimulation
A pilot treatment study for mild traumatic brain injury: Neuroimaging changes detected by MEG after low-intensity pulse-based transcranial electrical stimulation
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DOI：
10.1080/02699052.2017.1363409
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发表时间：
2017-01-01
期刊：
影响因子：
1.9
通讯作者：
Lee, Roland R.
中科院分区：
文献类型：
--
作者：
Huang, Ming-Xiong;Swan, Ashley Robb;Lee, Roland R.
背景：轻度创伤性脑损伤（mTBI）是军人、退伍军人和平民持续性损伤的主要原因。然而，很少有治疗方法可用于mTBI，部分原因是持续性mTBI缺陷的机制尚未完全了解。帕拉;&帕拉;研究方法：我们使用脑磁图（MEG）来研究mTBI患者在被动神经反馈治疗计划（称为IASIS）后的神经元变化。该方案涉及使用经颅电刺激（LIP-tES）和脑电图监测施加低强度脉冲。研究参与者包括6名患有mTBI和持续性脑震荡后症状（PCS）的个体。在基线和随访时进行MEG检查，以评估IASIS对脑功能的影响。结果：在基线MEG检查时，所有参与者都有异常的慢波。在后续的MEG检查中，参与者显示异常慢波显著减少，慢波总分平均减少53.6 +/- 24.6%。参与者在IASIS治疗后PCS评分也显着降低，PCS总分平均降低52.76 +/- 26.4%。帕拉;&帕拉;结论：本研究首次证明了LIP-tES治疗对mTBI脑功能影响的神经影像学记录。讨论了LIP-tES治疗的机制，重点是LIP-tES对mTBI愈合过程的增强作用。
Background: Mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members, Veterans, and civilians. However, few treatments are available for mTBI, partially because the mechanism of persistent mTBI deficits is not fully understood.& para;& para;Methods: We used magnetoencephalography (MEG) to investigate neuronal changes in individuals with mTBI following a passive neurofeedback-based treatment programme called IASIS. This programme involved applying low-intensity pulses using transcranial electrical stimulation (LIP-tES) with electroencephalography monitoring. Study participants included six individuals with mTBI and persistent post-concussive symptoms (PCS). MEG exams were performed at baseline and follow-up to evaluate the effect of IASIS on brain functioning.& para;& para;Results: At the baseline MEG exam, all participants had abnormal slow-waves. In the follow-up MEG exam, the participants showed significantly reduced abnormal slow-waves with an average reduction of 53.6 +/- 24.6% in slow-wave total score. The participants also showed significant reduction o f PCS scores after IASIS treatment, with an average reduction of 52.76 +/- 26.4% in PCS total score.& para;& para;Conclusions: The present study demonstrates, for the first time, the neuroimaging-based documentation of the effect of LIP-tES treatment on brain functioning in mTBI. The mechanisms of LIP-tES treatment are discussed, with an emphasis on LIP-tES's potentiation of the mTBI healing process.