The influence of MHC and immunoglobulins a and e on host resistance to gastrointestinal nematodes in sheep.
The influence of MHC and immunoglobulins a and e on host resistance to gastrointestinal nematodes in sheep.
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DOI：
10.1155/2011/101848
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发表时间：
2011
影响因子：
2.2
通讯作者：
Groth DM
中科院分区：
文献类型：
--
作者：
Lee CY;Munyard KA;Gregg K;Wetherall JD;Stear MJ;Groth DM
养殖动物中的胃肠道线虫寄生虫由于其对生产的影响而特别重要。在澳大利亚，据估计寄生虫感染的直接和间接影响每年使动物生产行业损失数亿美元。免疫学家在研究胃肠道线虫感染时考虑的主要因素是宿主的反应对寄生虫的影响，其中免疫成分负责这些影响，参与控制免疫反应的遗传因素，以及这些因素之间的相互作用形成相互关联的多级关系。在本文中，我们描述了免疫球蛋白，特别是伊加和IgE，和主要组织相容性复合体在抵抗绵羊胃肠道寄生虫的作用。我们还从其他动物模型中获得证据，以支持这些免疫成分的参与。最后，我们研究了伊加和IgE如何发挥其影响力，以及如何开发方法来管理易感动物。
Gastrointestinal nematode parasites in farmed animals are of particular importance due to their effects on production. In Australia, it is estimated that the direct and indirect effects of parasite infestation cost the animal production industries hundreds of millions of dollars each year. The main factors considered by immunologists when studying gastrointestinal nematode infections are the effects the host's response has on the parasite, which immunological components are responsible for these effects, genetic factors involved in controlling immunological responses, and the interactions between these forming an interconnecting multilevel relationship. In this paper, we describe the roles of immunoglobulins, in particular IgA and IgE, and the major histocompatibility complex in resistance to gastrointestinal parasites in sheep. We also draw evidence from other animal models to support the involvement of these immune components. Finally, we examine how IgA and IgE exert their influence and how methods may be developed to manage susceptible animals.