The IL-33-ST2-MyD88 axis promotes regulatory Tcell proliferation in the murine liver
The IL-33-ST2-MyD88 axis promotes regulatory Tcell proliferation in the murine liver
复制标题
IL-33-ST2-MyD88轴促进小鼠肝脏中调节性T细胞增殖
DOI：
10.1002/eji.201747402
复制
发表时间：
2018
影响因子：
5.4
通讯作者：
Su C
中科院分区：
文献类型：
--
作者：
Xu Lei;Li Wei;Wang Xiaofan;Zhang Lina;Qi Qianqian;Dong Liyang;Wei Chuan;Pu Yanan;Li Yalin;Zhu Jifeng;Zhou Sha;Liu Feng;Chen Xiaojun;Su Chuan;Chen XJ;Su C
肝脏 Foxp3+Treg 细胞对于维持肝脏局部免疫稳态至关重要。然而，肝脏 Treg 细胞稳态所需的环境线索尚不清楚。在这项研究中，我们发现IL-33受体ST2优先在小鼠肝脏的Treg细胞上表达，但在脾脏、肠系膜淋巴结和血液中表达较低。更重要的是，我们发现 IL-33 通过骨髓分化因子 MyD88 信号传导促进肝 Treg 细胞的增殖，同时增加细胞周期蛋白依赖性激酶 4 和细胞周期蛋白 D1 的表达。这些结果表明，IL-33 是一种潜在的组织特异性因子，通过增加肝脏中的 Treg 增殖来控制 Treg 细胞稳态。
Hepatic Foxp3+Treg cells are crucial for maintaining local immune homeostasis in the liver. However, the environmental cues required for hepatic Treg cell homeostasis are unclear. In this study, we showed that the IL‐33 receptor ST2 was preferentially expressed on Treg cells in the mouse liver, but it was more lowly expressed in the spleen, mesenteric lymph nodes, and blood. More importantly, we found that IL‐33 promoted the proliferation of hepatic Treg cells through myeloid differentiation factor MyD88 signaling concomitant with increased cyclin‐dependent kinase 4 and cyclin D1 expression. These results suggest that IL‐33 is a potential tissue‐specific factor controlling Treg cell homeostasis via increased Treg proliferation in the liver.