The Immunohistochemical Mucin Expression Pattern Distinguishes Different Types of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Determines Their Relationship to Mucinous Noncystic Carcinoma and Ductal Adenocarcinoma
The Immunohistochemical Mucin Expression Pattern Distinguishes Different Types of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Determines Their Relationship to Mucinous Noncystic Carcinoma and Ductal Adenocarcinoma
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免疫组织化学粘蛋白表达模式可区分不同类型的胰腺导管内乳头状粘液性肿瘤，并确定其与粘液性非囊性癌和导管腺癌的关系
DOI：
10.1097/00000478-200107000-00014
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
G. Klöppel
中科院分区：
文献类型：
--
作者：
J. Lüttges;G. Zamboni;D. Longnecker;G. Klöppel
胰腺导管内乳头状黏液性肿瘤包括多种类型，其与导管腺癌和黏液性非囊性癌的关系尚不清楚。我们分析了导管内乳头状黏液性肿瘤、导管癌和黏液性非囊性癌中的黏液免疫表型和DPC 4/SMAD 4表达，以确定可能有助于区分不同类型导管内乳头状黏液性肿瘤的特征，并建立它们与胰腺外分泌部其他肿瘤的关系。一系列的51导管内乳头状粘液性肿瘤，3粘液性非囊性癌（两个与导管内成分），和35导管腺癌的MUC 1，MUC 2，MUC 5，DPC 4/SMAD 4的表达进行了筛选。所有导管内乳头状粘液性肿瘤和粘液性非囊性癌均为MUC 5阳性。32例导管内乳头状粘液性肿瘤和3例粘液性非囊性癌大量表达MUC 2，但无（或仅有少量）MUC 1。其余导管内乳头状粘液性肿瘤主要表现为MUC 1表达或局灶性MUC 1和MUC 2表达。所有导管癌，但一个是MUC 2阴性和MUC 1和MUC 5阳性。DPC 4在两个表现为管状浸润模式的导管内乳头状粘液性肿瘤中不表达。23例导管腺癌中12例DPC 4阳性。导管内乳头状粘液性肿瘤可分为至少三种不同的粘蛋白免疫表型。第一组和最大组的导管内乳头状粘液性肿瘤和粘液性非囊性癌是MUC 1阴性和MUC 2阳性，可能形成一个肿瘤实体。第二组似乎与导管癌有关，因为其MUC 1阳性而MUC 2染色不存在或非常弱。第三组显示局灶性MUC 1/MUC 2表达，并以嗜酸性细胞组织学为特征。
Intraductal papillary-mucinous neoplasms of the pancreas seem to comprise various types, whose relationship to ductal adenocarcinoma and mucinous noncystic carcinoma is unclear. We analyzed the mucin immunophenotype and the DPC4/SMAD4 expression in intraductal papillary-mucinous neoplasms, ductal carcinomas, and mucinous noncystic carcinomas to define features that may help to distinguish between different types of intraductal papillary-mucinous neoplasms and to establish their relationship to other neoplasms of the exocrine pancreas. A series of 51 intraductal papillary-mucinous neoplasms, three mucinous noncystic carcinomas (two with an intraductal component), and 35 ductal adenocarcinomas were screened immunohistochemically for their expression of MUC1, MUC2, MUC5, and DPC4/SMAD4. All intraductal papillary-mucinous neoplasms and mucinous noncystic carcinomas were positive for MUC5. Thirty-two intraductal papillary-mucinous neoplasms and three mucinous noncystic carcinomas abundantly expressed MUC2 but no (or only little) MUC1. The remaining intraductal papillary-mucinous neoplasms showed either mainly MUC1 expression or focal MUC1 and MUC2 expression. All ductal carcinomas but one were MUC2 negative and MUC1 and MUC5 positive. DPC4 was not expressed in two intraductal papillary-mucinous neoplasms that showed a tubular invasion pattern. Twelve of 23 ductal adenocarcinomas were DPC4 positive. Intraductal papillary-mucinous neoplasms can be divided into at least three different mucin immunophenotypes. The first and largest group of intraductal papillary-mucinous neoplasms and mucinous noncystic carcinomas is MUC1 negative and MUC2 positive and probably forms one tumor entity. The second group seems to be related to ductal carcinoma because of its MUC1 positivity in the absence or very weak MUC2 staining. The third group shows focal MUC1/MUC2 expression and is characterized by oncocytic histology.
粘蛋白表达的改变是伴随粘液性（胶体）乳腺癌组织发生的一系列变化。
影响因子：
3.3
作者：
O'Connell,JT;Shao,ZM;Drori,E;Basbaum,CB;Barsky,SH
通讯作者：
Barsky,SH
MUC2基因在非侵袭性肿瘤中发现表达，但在胰腺和肝脏的侵袭性肿瘤中不表达：其与患者的预后密切相关。
影响因子：
3.3
作者：
Yonezawa,S;Sueyoshi,K;Nomoto,M;Kitamura,H;Nagata,K;Arimura,Y;Tanaka,S;Hollingsworth,MA;Siddiki,B;Kim,YS;Sato,E
通讯作者：
Sato,E