The Claustrum-Prefrontal Cortex Pathway Regulates Impulsive-Like Behavior
The Claustrum-Prefrontal Cortex Pathway Regulates Impulsive-Like Behavior
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DOI：
10.1523/jneurosci.1005-19.2019
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发表时间：
2019-12-11
影响因子：
5.3
通讯作者：
Li, Jun-Xu
中科院分区：
文献类型：
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作者：
Liu, Jianfeng;Wu, Ruyan;Li, Jun-Xu
屏状核与包括前额叶皮质（PFC）在内的广泛的皮质区域相连。然而，屏状核（CLA）及其神经投射的功能在很大程度上仍然未知。在这里，我们阐明了从CIA到PFC的神经投射在调节雄性大鼠冲动中的作用。我们首先通过逆行示踪和病毒表达鉴定了CLA-PFC途径。通过使用c-Fos阳性神经元的免疫荧光染色，我们发现，化学发生激活和抑制CLA-PFC途径减少和增加PFC的整体活性，分别。在5-选择系列反应时间任务（5-CSRTT）中，我们发现CLA-PFC通路的化学发生激活和抑制增加和减少了冲动样行为（即，提前响应）。此外，CLA-PFC途径的化学发生抑制防止甲基苯丙胺诱导的冲动，而不影响甲基苯丙胺诱导的多动症。与CLA-PFC通路在选择性调节冲动性中的作用相反，屏状核的激活在5-CSRTT中破坏了注意力。这些结果表明，CLA-PFC途径是必不可少的冲动。这项研究可能有助于理解与冲动有关的疾病，如药物成瘾。
The claustrum connects with a broad range of cortical areas including the prefrontal cortex (PFC). However, the function of the claustrum (CLA) and its neural projections remains largely unknown. Here, we elucidated the role of the neural projections from the CIA to the PFC in regulating impulsivity in male rats. We first identified the CLA-PFC pathway by retrograde tracer and virus expression. By using immunofluorescent staining of the c-Fos-positive neurons, we showed that chemogenetic activation and inhibition of the CLA-PFC pathway reduced and increased overall activity of the PFC, respectively. In the 5-choice serial reaction time task (5-CSRTT), we found that chemogenetic activation and inhibition of the CLA-PFC pathway increased and reduced the impulsive-like behavior (i.e., premature responses), respectively. Furthermore, chemogenetic inhibition of the CLA-PFC pathway prevented methamphetamine-induced impulsivity, without affecting methamphetamine-induced hyperactivity. In contrast to the role of CLA-PFC pathway in selectively regulating impulsivity, activation of the claustrum disrupted attention in the 5-CSRTT. These results indicate that the CLA-PFC pathway is essential for impulsivity. This study may shed light on the understanding of impulsivity-related disorders such as drug addiction.