Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques.
Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques.
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DOI：
10.1038/s41598-017-10901-1
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发表时间：
2017-09-05
影响因子：
4.6
通讯作者：
Mattapallil JJ
中科院分区：
文献类型：
--
作者：
George J;Valiant WG;Mattapallil MJ;Walker M;Huang YS;Vanlandingham DL;Misamore J;Greenhouse J;Weiss DE;Verthelyi D;Higgs S;Andersen H;Lewis MG;Mattapallil JJ
寨卡病毒和登革热病毒包膜蛋白之间的结构和功能同源性提高了寨卡病毒感染后诱导的交叉反应抗体可能增强随后的登革热感染的可能性。使用恒河猴模型，我们表明先前感染寨卡病毒会导致登革2型病毒血症显着增强，并伴有中性粒细胞减少症、淋巴细胞增多症、高血糖症和较高的网织红细胞计数，以及促炎单核细胞亚群的激活和炎症介质的释放。沿着。寨卡病毒感染诱导可检测到的登革热交叉反应性血清IgG应答，这些应答在登革热2型病毒感染后显著扩增。来自在登革-2感染之前收集的寨卡病毒免疫动物的血清显示出登革-1、2、3和4血清型的体外抗体依赖性增强的显著能力，这表明对寨卡病毒的预先存在的免疫可能潜在地增强异源登革血清型的感染。我们的研究结果提供了第一个体内证据，表明先前暴露于寨卡病毒感染可以增强登革热感染，这对理解发病机制和疫苗开发具有重要意义。
Structural and functional homologies between the Zika and Dengue viruses’ envelope proteins raise the possibility that cross-reactive antibodies induced following Zika virus infection might enhance subsequent Dengue infection. Using the rhesus macaque model we show that prior infection with Zika virus leads to a significant enhancement of Dengue-2 viremia that is accompanied by neutropenia, lympocytosis, hyperglycemia, and higher reticulocyte counts, along with the activation of pro-inflammatory monocyte subsets and release of inflammatory mediators. Zika virus infection induced detectable Dengue cross-reactive serum IgG responses that significantly amplified after Dengue-2 virus infection. Serum from Zika virus immune animals collected prior to Dengue-2 infection showed significant capacity for in vitro antibody dependent enhancement of Dengue-1, 2, 3 and 4 serotypes suggesting that pre-existing immunity to Zika virus could potentially enhance infection by heterologous Dengue serotypes. Our results provide first in vivo evidence that prior exposure to Zika virus infection can enhance Dengue infection, which has implications for understanding pathogenesis and the development of vaccines.
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影响因子：
30.3
作者：
Beltramello M;Williams KL;Simmons CP;Macagno A;Simonelli L;Quyen NT;Sukupolvi-Petty S;Navarro-Sanchez E;Young PR;de Silva AM;Rey FA;Varani L;Whitehead SS;Diamond MS;Harris E;Lanzavecchia A;Sallusto F
通讯作者：
Sallusto F
DOI：
10.4269/ajtmh.1973.22.375
发表时间：
1973-01-01
影响因子：
3.3
作者：
HALSTEAD, SB;PALUMBO, NE
通讯作者：
PALUMBO, NE
影响因子：
3.3
作者：
Hickey, Andrew C.;Koster, Jacob A.;Bossart, Katharine N.
通讯作者：
Bossart, Katharine N.
影响因子：
5.2
作者：
Clark KB;Onlamoon N;Hsiao HM;Perng GC;Villinger F
通讯作者：
Villinger F
影响因子：
82.9
作者：
Osuna CE;Lim SY;Deleage C;Griffin BD;Stein D;Schroeder LT;Omange RW;Best K;Luo M;Hraber PT;Andersen-Elyard H;Ojeda EF;Huang S;Vanlandingham DL;Higgs S;Perelson AS;Estes JD;Safronetz D;Lewis MG;Whitney JB
通讯作者：
Whitney JB