Five-membered ring azasugars as potent inhibitors of alpha-L-rhamnosidase (naringinase) from Penicillium decumbens.
Five-membered ring azasugars as potent inhibitors of alpha-L-rhamnosidase (naringinase) from Penicillium decumbens.
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DOI：
10.1016/s0968-0896(00)82069-6
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发表时间：
1994-11-01
影响因子：
3.5
通讯作者：
Wong, C H
中科院分区：
文献类型：
--
作者：
Provencher, L;Steensma, D H;Wong, C H
合成了具有L-鼠李糖构型的五元环氮杂糖作为来自斜卧青霉的α-L-鼠李糖苷酶的抑制剂。所有测试的化合物都在微M或亚微M范围内。氮原子的取代使抑制机制从混合型转变为竞争型。
Five-membered ring azasugars with the L-rhamnose configuration were synthesized as inhibitors of alpha-L-rhamnosidase from Penicillium decumbens. All compounds tested were in the microM or sub-microM range. Substitution at the nitrogen shifted the inhibition mechanism from mixed to competitive.