Cell density and mobility protect swarming bacteria against antibiotics
Cell density and mobility protect swarming bacteria against antibiotics
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DOI：
10.1073/pnas.0910934107
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发表时间：
2010-02-23
影响因子：
11.1
通讯作者：
Harshey, Rasika M.
中科院分区：
文献类型：
--
作者：
Butler, Mitchell T.;Wang, Qingfeng;Harshey, Rasika M.
蜂群细菌以多细胞群体的形式移动，对多种抗生素表现出适应性耐药性。对这一现象的分析揭示了高细胞密度的保护能力，以承受暴露于否则致命的抗生素浓度。我们发现，即使在非蜂群状态下，高密度也能促进细菌存活，但移动的能力和移动的速度赋予了细菌额外的优势，使蜂群成为对抗抗菌剂的有效策略。我们没有发现诱导耐药途径或群体感应机制控制这一群体耐药的证据，这是以直接暴露于抗生素的细胞为代价的。这项工作与细菌生物膜的适应性抗生素耐药性有关。
Swarming bacteria move in multicellular groups and exhibit adaptive resistance to multiple antibiotics. Analysis of this phenomenon has revealed the protective power of high cell densities to withstand exposure to otherwise lethal antibiotic concentrations. We find that high densities promote bacterial survival, even in a nonswarming state, but that the ability to move, as well as the speed of movement, confers an added advantage, making swarming an effective strategy for prevailing against antimicrobials. We find no evidence of induced resistance pathways or quorum-sensing mechanisms controlling this group resistance, which occurs at a cost to cells directly exposed to the antibiotic. This work has relevance to the adaptive antibiotic resistance of bacterial biofilms.