Serum Cholinesterase Activity During Pregnancy, Labor and the Puerperium
Serum Cholinesterase Activity During Pregnancy, Labor and the Puerperium
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妊娠、分娩和产褥期血清胆碱酯酶活性
DOI：
10.1097/00000542-196505000-00010
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发表时间：
1965
期刊：
影响因子：
8.8
通讯作者：
S. Shnider
中科院分区：
文献类型：
--
作者：
S. Shnider
在30名健康产科患者中，在临产期间、产后1天和产后3天进行血清胆碱酯酶测定。十名患者在怀孕后期和产后 6 周接受了研究。与产后 6 周测定的非妊娠值相比，妊娠后期酶活性下降 27.7%，分娩期间下降 15.6%，产后一天下降 24.6%，两天后下降 32.3%。与分娩期间的值相比，超过90%的患者在产后三天胆碱酯酶活性下降。在妊娠后期和分娩期间，10%的患者发现胆碱酯酶值较低（低于55单位/毫升），产后一天的患者有20%，两天后的患者有60%。有一个病例在使用400毫克后出现长期瘫痪。剖腹产期间使用琥珀胆碱。随后的研究发现血清胆碱酯酶活性异常低，但酶质量正常。
In 30 healthy obstetrical patients, determinations of serum cholinesterase were performed during labor, one day and three days postpartum. Ten patients were studied late in pregnancy and 6 weeks postpartum. Compared to nonpregnant values as determined 6 weeks postpartum, there was a 27.7 per cent reduction of enzyme activity during late pregnancy, a 15.6 per cent decrease during labor, a 24.6 per cent decrease one day postpartum, and a 32.3 per cent decrease two days later. Compared to values during labor, over 90 per cent had falls of cholinesterase activity three days postpartum.Low cholinesterase values (below 55 units per ml.) were found in 10 per cent of patients in late pregnancy and during labor, in 20 per cent of patients one day postpartum, and in 60 per cent of patients two days later.A case is presented of prolonged paralysis following the use of 400 mg. succinylcholine during cesarean section. Subsequent studies disclosed abnormally low serum cholinesterase activity, but a qualitatively normal enzyme.