Histone methylation in DNA repair and clinical practice: new findings during the past 5-years.
Histone methylation in DNA repair and clinical practice: new findings during the past 5-years.
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DNA修复和临床实践中的组蛋白甲基化：过去5年的新发现
DOI：
10.7150/jca.23427
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发表时间：
2018
影响因子：
3.9
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Wei S;Li C;Yin Z;Wen J;Meng H;Xue L;Wang J
DNA双链断裂（DSB）是一种高毒性损伤，可损害细胞内稳态和基因组稳定性，导致肿瘤发生的不适当修复。尽管DSB的修复可以通过同源重组（HR）或非同源末端连接（NHEJ）进行，但相关机制仍不完全清楚。事实上，越来越多的证据表明，组蛋白赖氨酸甲基化在DNA修复途径的选择中起着重要作用。例如，三甲基化的H3K36是HR修复所需的，而二甲基化的H4K20可以募集53BP1用于NHEJ修复。本文就组蛋白甲基化在DNA双链断裂修复中的作用机制作一综述。深入了解组蛋白甲基化修复DNA损伤的机制将为临床肿瘤治疗提供重要线索。
DNA double-strand breaks (DSBs) are highly toxic lesions that can impair cellular homeostasis and genome stability to result in tumorigenesis for inappropriate repair. Although DSBs are repaired by homologous recombination (HR) or non-homologous end-joining (NHEJ), the related mechanisms are still incompletely unclear. Indeed, more and more evidences indicate that the methylation of histone lysine has an important role in choosing the pathways of DNA repair. For example, tri-methylated H3K36 is required for HR repair, while di-methylated H4K20 can recruit 53BP1 for NHEJ repair. Here, we reviewed the recent progress in the molecular mechanisms by which histone methylation functions in DNA double-strand breaks repair (DSBR). The insight into the mechanisms of histone methylation repairing DNA damage will supply important cues for clinical cancer treatment.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
4.5
作者：
Amendola PG;Zaghet N;Ramalho JJ;Vilstrup Johansen J;Boxem M;Salcini AE
通讯作者：
Salcini AE
影响因子：
16.8
作者：
Daugaard, Mads;Baude, Annika;Jaattela, Marja
通讯作者：
Jaattela, Marja
影响因子：
16
作者：
Altaf, Mohammed;Utley, Rhea T.;Cote, Jacques
通讯作者：
Cote, Jacques
影响因子：
14.8
作者：
Bromberg, Kenneth D.;Mitchell, Taylor R. H.;Pappano, William N.
通讯作者：
Pappano, William N.