Design And Evaluation Of Propranolol Hydrochloride Buccal Films

Design And Evaluation Of Propranolol Hydrochloride Buccal Films
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盐酸普萘洛尔颊膜的设计与评价

DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
V. Sankar
V. Sankar
中科院分区：
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文献类型：
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作者：
S. Raghuraman;G. Velrajan;R. Ravi;B. Jeyabalan;D. Johnson;V. Sankar

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使用不同比例和组合的三种不同聚合物制备盐酸普萘洛尔颊膜。评估了重量变化、厚度、耐折性、药物含量、吸湿百分率和失水百分率等理化参数。设计了一项体外研究，并使用商业半透膜进行。制剂F6（含有6%乙基纤维素（EC）+ 0.5%聚乙烯吡咯烷酮（PVP）和8% EC作为控速膜的药物储库）的体外释放曲线显示出长达24小时的持续释放。它也服从一级动力学。在兔子身上进行的研究证实了其持续释放。
Propranolol hydrochloride buccal films were prepared using three different polymers in various proportions and combinations. The physicochemical parameters like weight variation, thickness, folding endurance, drug content, percentage moisture absorption and percentage moisture loss were evaluated. An in vitro study was designed and it was carried out using commercial semipermeable membrane. In vitro release profile for the formulation F6 (drug reservoir with 6% ethyl cellulose (EC)+ 0.5% polyvinyl pyrolidone (PVP) and 8% EC as rate controlling membrane) showed sustained release upto 24 h. It also obeyed first order kinetics. The studies conducted in rabbits confirmed the sustained release.