Childhood exercise predicts response inhibition in later life via changes in brain connectivity and structure
Childhood exercise predicts response inhibition in later life via changes in brain connectivity and structure
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DOI：
10.1016/j.neuroimage.2021.118196
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发表时间：
2021-05-29
期刊：
影响因子：
5.7
通讯作者：
Matsuda, Tetsuya
中科院分区：
文献类型：
--
作者：
Ishihara, Toru;Miyazaki, Atsushi;Matsuda, Tetsuya
在生命早期（即从童年到青春期）参与锻炼可以增强反应抑制；然而，尚不清楚早期参与运动是否能积极预测晚年的反应抑制。这项历史队列研究旨在阐明早期参与运动（例如，有组织的运动参与）是否能预测成年后的反应抑制，如果是这样，则揭示大脑连通性和皮层结构对这种关联的影响。我们分析了214名参与者的数据（女性= 104，男性= 110，年龄：26 -69岁）。结果表明：儿童时期（进入初中之前；= 12岁）参与运动。儿童时期运动参与与反应抑制的正相关被额顶叶（FPN）、扣谷-眼窝（CON）和默认模式网络（DMN）的结构和功能连通性下降以及半球间结构网络的增加所缓和。在FPN、CON和DMN中，更大的皮质厚度和更低水平的树突树突和密度也缓和了这种正相关。我们的研究结果表明，儿童时期参与运动可以积极预测以后生活中的反应抑制，并且这种关联可以通过神经元回路的变化来调节，例如皮质厚度和效率的增加，以及半球间连通性的加强。
Participation in exercise during early life (i.e., childhood through adolescence) enhances response inhibition; however, it is unclear whether participation in exercise during early life positively predicts response inhibition in later life. This historical cohort study was designed to clarify whether participation in exercise (e.g., structured sports participation) during early life predicts response inhibition in adulthood and if so, to reveal the brain connectivity and cortical structures contributing to this association. We analyzed data derived from 214 participants (women = 104, men = 110; age: 26 -69 years). Results indicated that participation in exercise during childhood (before entering junior high school; = 12 years old). The positive association of exercise participation during childhood with response inhibition was moderated by decreased structural and functional connectivity in the frontoparietal (FPN), cingulo-opercular (CON), and default mode networks (DMN), and increased inter-hemispheric structural networks. Greater cortical thickness and lower levels of dendritic arborization and density in the FPN, CON, and DMN also moderated this positive association. Our results suggest that participation in exercise during childhood positively predicts response inhibition later in life and that this association can be moderated by changes in neuronal circuitry, such as increased cortical thickness and efficiency, and strengthened inter-hemispheric connectivity.