The effects of chronic electrical stimulation on laryngeal muscle reinnervation.
The effects of chronic electrical stimulation on laryngeal muscle reinnervation.
复制标题
慢性电刺激对喉部肌肉神经支配的影响。
DOI：
10.1159/000027723
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Herzon,GD
中科院分区：
文献类型：
--
作者：
Zealear,DL;Billante,CL;Chongkolwatana,C;Herzon,GD
本研究探讨了功能性神经肌肉刺激 (FNS) 对环杓后肌 (PCA) 肌肉神经支配的影响。在 4 只犬齿中，将喉返神经 (RLN) 切开并吻合，并植入贴片电极阵列以在多个 PCA 部位进行刺激和记录。植入后，将 FNS 应用于 2 只犬齿，为期 6 周。另外两只动物作为未刺激的对照。在每只动物中，使用 RLN 的组织形态学分析来评估神经再生的质量和肌肉重新连接的潜力。通过 RLN 刺激引起的肌电图 (EMG) 电位来监测神经支配的程度。重新连接的适当性取决于自发肌电图活动的模式和声带外展的恢复。这项初步研究的结果表明，FNS 导致神经支配的全面抑制。然而，抑制优先抑制外来神经纤维的重新连接，促进选择性神经支配并防止联带作用。
The present study examined the effects of functional neuromuscular stimulation (FNS) on reinnervation of the posterior cricoarytenoid (PCA) muscle. In 4 canines, the recurrent laryngeal nerve (RLN) was sectioned and anastomosed and a patch electrode array implanted for stimulation and recording at multiple PCA sites. Following implantation, FNS was applied to 2 canines for a period of 6 weeks. Two additional animals served as nonstimulated controls. In each animal, histomorphometric analysis of the RLN was used to assess the quality of nerve regeneration and the potential for muscle reconnection. The magnitude of reinnervation was monitored by electromyographic (EMG) potentials evoked by RLN stimulation. The appropriateness of reconnection was determined by the pattern of spontaneous EMG activity and recovery of vocal fold abduction. Results of this preliminary study indicated that FNS caused an overall repression of reinnervation. However, the repression preferentially inhibited reconnection by foreign nerve fibers, promoting selective reinnervation and preventing synkinesis.