A new isomaneonene derivative from the red alga Laurencia cf. mariannensis
A new isomaneonene derivative from the red alga Laurencia cf. mariannensis
复制标题
DOI：
10.1080/10286020.2022.2130266
复制
发表时间：
2022-10
影响因子：
1.7
通讯作者：
T. Ishii;Arisu Tahara;Kanako Taba;M. Iwatsuki;Masako Honsho;Yukihiro Asami;K. Nonaka;H. Hanaki;T. Teruya
中科院分区：
文献类型：
--
作者：
T. Ishii;Arisu Tahara;Kanako Taba;M. Iwatsuki;Masako Honsho;Yukihiro Asami;K. Nonaka;H. Hanaki;T. Teruya
摘要确定海洋物种新天然产物的结构不仅丰富了我们对这些物种的多样性化学的理解，而且还可以发现具有新的和/或重要生物活性的化合物。本文报道了从红顶凹顶日本冲绳伊平屋岛的mariannensis。这些次级代谢产物的结构通过光谱法进行了解析。所有化合物在与β-内酰胺药物美罗培南联合治疗时，在30 μg/片时对耐甲氧西林金黄色葡萄球菌（MRSA）无活性。图形摘要
Abstract Determining the structures of new natural products from marine species not only enriches our understanding of the diverse chemistry of these species, but can also lead to the discovery of compounds with novel and/or important biological activities. Herein, we describe the isolation of isomaneonene C (1), a new halogenated C15 acetogenin, and three known compounds, α-snyderol (2), cis-maneonene D (3), and isomaneonene B (4), from the organic extract obtained from the red alga Laurencia cf. mariannensis collected from Iheya Island, Okinawa, Japan. The structures of these secondary metabolites were elucidated spectroscopically. All compounds were inactive at 30 μg/disc against methicillin-resistant Staphylococcus aureus (MRSA) in combination treatment with a β-lactam drug, meropenem. Graphical Abstract