Effective early detection of oral cancer using a simple and inexpensive point of care device in oral rinses
Effective early detection of oral cancer using a simple and inexpensive point of care device in oral rinses
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DOI：
10.1080/14737159.2018.1523008
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发表时间：
2018-01-01
影响因子：
5.1
通讯作者：
Donovan, Michael J.
中科院分区：
文献类型：
--
作者：
Franzmann, Elizabeth J.;Donovan, Michael J.
导言：头颈癌仍然是一种具有挑战性的疾病，其发病率正在增加，大多数患者在诊断为晚期患者时，5年生存率约为50%。目前的方法包括口腔刷检、基于荧光的技术和唾液分子图谱，已经证明了一些成功，然而，成本、易用性和准确性仍然是限制因素。覆盖范围：这是一种新的、易于使用的口腔冲洗护理点(POC)测试的概况，以辅助口腔和口咽癌的诊断。背景提供了与口腔和口咽癌的挑战相关的科学，以及该疾病的诊断辅助工具的自然历史。专家评论：POC测试已经通过病例对照临床研究和使用1.0版(v1.0)的欧洲预期试验进行了验证，它们表现出一致的性能，包括90%的阴性预测值，灵敏度为80%。该分析旨在通过改进标准的临床评估来识别口腔和口咽部的恶性病变。
Introduction: Head and neck cancer remains a challenging disease that is increasing in incidence with the majority of patients diagnosed at an advanced stage where 5-year survival is approximately 50%. Current approaches including oral-brush biopsies, fluorescence-based technologies, and salivary molecular profiling have demonstrated some success; however, cost, ease of use, and accuracy remain limiting factors.Areas covered: This is a profile of a novel, easy to use oral rinse point-of-care (POC) test to aid in the diagnosis of oral and oropharyngeal cancer. Background science related to the challenge of oral and oropharyngeal cancer and natural history of diagnostic aids for this disease are provided. Results of studies performed for validation of a POC and laboratory test are also discussed.Expert commentary: The POC test has been validated through a case : control clinical study and a prospective European trial, using version 1.0 (v1.0), which have demonstrated consistent performance including a > 90% negative predictive value, with a sensitivity of 80%. The assay was designed to identify malignant lesions in the oral cavity and oropharynx by improving upon standard clinical assessment.