Dendritic cells presenting tumor antigen
Dendritic cells presenting tumor antigen
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DOI：
10.1007/s002620050317
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发表时间：
1996-11-01
影响因子：
5.8
通讯作者：
Shurin, MR
中科院分区：
文献类型：
--
作者：
Shurin, MR
自1973年Steinman和Cohn首次发现树突状细胞以来，对树突状细胞生物学的研究取得了进展，包括发展了新的细胞培养方法，认识到迁移和成熟的关键方面，认识到树突状细胞作为抗原提呈细胞(APC)的主要作用，以及这种活性如何受细胞因子和辅助分子的表达调节。树突状细胞是启动免疫应答和形成免疫耐受的主要抗原前体细胞。有相当多的证据表明，它们可以在周围组织中获得抗原，并将其加工、运输并呈递给次级淋巴组织中的T细胞。许多研究表明，在体外或体内，抗原冲击的树突状细胞可以直接敏化T细胞，刺激抗原特异性免疫反应的发展，包括保护性和治疗性抗肿瘤反应。本文就树突状细胞生物学的几个重要方面进行了讨论，并对证实这些专业性APC在抗肿瘤免疫中的作用的一些研究进行了综述。
Since the first identification of dendritic cells by Steinman and Cohn in 1973, progress in understanding their biology has included the development of novel methods of cell culture, recognition of critical aspects of migration and maturation, and appreciation of their major role as antigen-presenting cells (APC), and how this activity is regulated by cytokines and expression of accessory molecules. Dendritic cells are the major APC involved in the initiation of the immune response and the development of tolerance. There is considerable evidence that they can acquire antigen in the peripheral tissues and process, transport, and present it to T cells in secondary lymphoid tissue. A number of studies show that, in vitro or in vivo, antigen-pulsed dendritic cells can directly sensitize T cells and stimulate the development of antigen-specific immune responses, including both protective and therapeutic antitumor responses. In this paper, several important aspects of dendritic cell biology are discussed and a number of studies confirming the role of these professional APC in antitumor immunity are reviewed.