Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men.
Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men.
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三天的无热量、低碳水化合物/高脂肪饮食可以增加健康非肥胖日本男性的胰岛素清除率。
DOI：
10.1038/s41598-019-40498-6
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Watada H.
中科院分区：
文献类型：
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作者：
Suzuki R;Tamura Y;Takeno K;Kakehi S;Funayama T;Furukawa Y;Kaga H;Sugimoto D;Kadowaki S;Someya Y;Kanazawa A;Kawamori R;Watada H.
胰岛素代谢清除率（MCRI）被认为有助于维持葡萄糖稳态，即使在健康受试者中也是如此。然而，在健康受试者中，低碳水化合物/高脂肪（LCHF）饮食对MCRI的影响尚不清楚。为了研究健康受试者中3天LCHF饮食对MCRI的影响，我们研究了42名健康的非肥胖日本男性。每名受试者食用有热量的LCHF饮食3天。在LCHF饮食之前和之后，使用1H-磁共振波谱测量肌细胞内脂质（IMCL）水平，并使用正葡萄糖高胰岛素钳夹评估葡萄糖输注速率（GIR）和MCRI。LCHF饮食使MCRI增加10%，葡萄糖钳夹期间稳态血清胰岛素（SSSI）和GIR分别降低10%和6%。为了进一步研究MCRI的作用，我们根据MCRI的中位%变化将受试者分为高应答者（HR）和低应答者（LR）组。LCHF饮食增加了HR组的IMCL，降低了葡萄糖钳夹期间的SSSI，而LR组的IMCL和SSSI没有改变。我们的研究结果表明，在健康的非肥胖日本男性中，3天的LCHF饮食增加了MCRI。这种变化似乎有利于在低碳水化合物可用性期间维持血糖。
Metabolic clearance rate of insulin (MCRI) is thought to help maintain glucose homeostasis even in healthy subjects. However, the effect of a low carbohydrate/high fat (LCHF) diet on MCRI in healthy subject remains unclear. To investigate the effect of a 3-day eucaloric LCHF diet on MCRI in healthy subjects, we studied 42 healthy non-obese Japanese men. Each subject consumed a eucaloric LCHF diet for 3 days. Before and after the LCHF diet, intramyocellular lipid (IMCL) levels were measured using1H-magnetic resonance spectroscopy, and glucose infusion rate (GIR) and MCRI were evaluated with a euglycemic hyperinsulinemic clamp. The LCHF diet increased MCRI by 10% and decreased steady state serum insulin (SSSI) and GIR during glucose clamp by 10% and 6%, respectively. To further investigate the role of MCRI, we divided subjects into high-responder (HR) and low-responder (LR) groups based on the median %change in MCRI. The LCHF diet increased IMCL and decreased SSSIduring glucose clamp in the HR group, while those were not altered in the LR group. Our results suggested that a 3-day eucaloric LCHF diet increases MCRI in healthy non-obese Japanese men. This change seemed to be beneficial in terms of maintaining euglycemia during low carbohydrate availability.