Diastolic abnormalities in systemic sclerosis: evidence for associated defective cardiac functional reserve.
Diastolic abnormalities in systemic sclerosis: evidence for associated defective cardiac functional reserve.
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系统性硬化症的舒张异常：相关心脏功能储备缺陷的证据。
DOI：
10.1136/ard.55.7.455
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发表时间：
1996
影响因子：
27.4
通讯作者：
M. Condorelli
中科院分区：
文献类型：
--
作者：
G. Valentini;D. Vitale;A. Giunta;S. Maione;G. Gerundo;M. Arnese;E. Tirri;N. Pelaggi;A. Giacummo;G. Tirri;M. Condorelli
目的：探讨系统性硬化症（SSc）患者舒张异常的模式以及心室充盈受损与收缩功能之间的关系。方法：24 名 SSc 患者在休息时和运动后接受了使用回声多普勒和门控血池心脏血管造影的 M 型和二维超声心动图检查。结果：24 名 SSc 患者中有 10 名检测到左心室舒张期舒张受损。这 10 名心室充盈受损的患者静息时的左心室射血分数与其余 14 名患者没有差异，但 10 名患者中有 8 名在运动期间射血分数未能增加，而 14 名心室充盈正常的患者中只有 2 名 (p = 0.003)。结论：左心室舒张受损是最近描述的硬皮病心脏病的一个特征。 SSc 的舒张功能障碍可能取决于心肌纤维化或心肌缺血，或两者兼而有之。人们发现它与心脏功能储备缺陷有关。然而，其预后意义仍有待阐明。
OBJECTIVE: To investigate the pattern of diastolic abnormalities in patients with systemic sclerosis (SSc) and the relationship between impaired ventricular filling and systolic function. METHODS: Twenty four patients with SSc underwent M-mode and two dimensional echocardiography using echo-Doppler and gated blood pool cardiac angiography, both at rest and after exercise. RESULTS: An impaired diastolic relaxation of the left ventricle was detected in 10 of the 24 patients with SSc. Left ventricular ejection fraction at rest in these 10 patients with impaired ventricular filling did not differ from that in the remaining 14 patients, but eight of the 10 failed to increase their ejection fraction during exercise, compared with two of the 14 with normal ventricular filling (p = 0.003). CONCLUSION: Impaired relaxation of the left ventricle is a recently described feature of scleroderma heart disease. Diastolic dysfunction in SSc could depend on myocardial fibrosis or myocardial ischaemia, or both. It was found to be associated with a defective cardiac functional reserve. However, its prognostic significance remains to be clarified.
系统性硬化症患者冷暴露引起的左心室功能障碍。
DOI：
10.1016/0002-9343(86)90711-4
发表时间：
1986
期刊：
The American journal of medicine
影响因子：
--
作者：
Ellis,WW;Baer,AN;Robertson,RM;Pincus,T;Kronenberg,MW
通讯作者：
Kronenberg,MW
不均匀性对狗左心室压力下降速率的影响。
DOI：
10.1152/ajpheart.1989.256.1.h222
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Lew,WY;Rasmussen,CM
通讯作者：
Rasmussen,CM