Increased prefrontal and hippocampal glutamate concentration in schizophrenia:: Evidence from a magnetic resonance spectroscopy study
Increased prefrontal and hippocampal glutamate concentration in schizophrenia:: Evidence from a magnetic resonance spectroscopy study
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DOI：
10.1016/j.biopsych.2005.04.041
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发表时间：
2005-11-01
影响因子：
10.6
通讯作者：
Olbrich, HM
中科院分区：
文献类型：
--
作者：
van Elst, LT;Valerius, G;Olbrich, HM
背景：谷氨酸能功能障碍与精神分裂症的病理生理有关。然而，到目前为止，精神分裂症患者大脑中谷氨酸浓度改变的直接证据有限。为验证谷氨酸能神经传递改变可能在精神分裂症发病机制中发挥作用这一假设，我们采用高场磁共振波谱仪测定了慢性精神分裂症患者前额叶皮层和海马中谷氨酸和谷氨酰胺的浓度。对21例精神分裂症患者和32例健康志愿者进行了临床检查和背外侧前额叶皮层和海马的短回波时间单体素磁共振波谱检查。结果：患者组前额叶皮层和海马谷氨酸的绝对浓度明显高于对照组。因子方差分析（ANOVA）显示，精神分裂症的持续时间，住院次数，或抗精神病药物的炒作和谷氨酸浓度之间没有显着的相互作用。增加前额叶谷氨酸浓度与较差的全球mental functioning.Conclusions：这是第一个研究报告，精神分裂症患者的前额叶和边缘区的谷氨酸水平增加。我们的数据支持精神分裂症患者的多巴胺能功能障碍的假设。
Background: Glutamatergic dysfunction has been implicated in the pathophysiology of schizophrenia. However, so far there is limited direct evidence of altered in vivo glutamate concentrations in the brains of patients with schizophrenia. To test the hypothesis that altered glutamatergic neurotransmission might play a role in the pathogenesis of schizophrenia, we measured glutamate and glutamine concentrations in the prefrontal cortex and the hippocampus of patients with chronic schizophrenia using high-field magnetic resonance spectroscopy.Methods. Twenty-one patients with schizophrenia and 32 healthy volunteers were examined clinically and by means of short echo time single voxel magnetic resonance spectroscopy of the dorsolateral prefrontal cortex and the hippocampus. Absolute concentrations of neurometabolites were calculated.Results: Absolute concentrations of glutamate were significantly higher in the prefrontal cortex and the hippocampus in the patient group. Factorial analysis of variance (ANOVA) revealed no significant interactions between duration of schizophrenia, number of hospitalizations, or hype of antipsychotic medication and glutamate concentrations. Increased prefrontal glutamate concentrations were associated with poorer global mental functioning.Conclusions: This is the first study that reports increased levels of glutamate in prefrontal and limbic areas in patients with schizophrenia. Our data support the hypothesis of glutamatergic dysfunction in schizophrenia.