Small animal absorbed radiation dose from serial micro-computed tomography imaging
Small animal absorbed radiation dose from serial micro-computed tomography imaging
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DOI：
10.1007/s11307-007-0080-9
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发表时间：
2007-03-01
影响因子：
3.1
通讯作者：
Russell, Stephen J.
中科院分区：
文献类型：
--
作者：
Carlson, Stephanie K.;Classic, Kelly L.;Russell, Stephen J.
目的：为了从一系列显微计算机断层扫描（CT）检查中确定对小鼠癌症异种移植物的辐射剂量，程序：使用在右侧腹部具有15-mm皮下胰腺癌异种移植物的裸鼠。使用氟化锂热释光剂量计测量皮下肿瘤和小鼠胰腺（模拟原位胰腺肿瘤模型）的辐射暴露。使用80 kVp、0.26 mA、0.156 mm层厚、256层、0.7 mm Al过滤和60秒图像采集时间（15 mA/秒）进行超快微型CT。Micro-CT成像采集重复四次。结果：我们测量一致的低肿瘤剂量（0.014至0.02戈伊，平均= 0.017戈伊）每次扫描。每次扫描胰腺区域的原位剂量也始终较低（0.014至0.018戈伊;平均= 0.016戈伊）。结论：小鼠超快微型CT系列成像期间传递的辐射剂量较低，并且可能低于影响肿瘤生长的阈值。
Purpose: To determine the radiation dose to mouse cancer xenografts from serial micro-computed tomography (CT) examinations.Procedures: A nude mouse with a 15-mm subcutaneous pancreatic cancer xenograft in the rightflank was used. Radiation exposure to the subcutaneous tumor and the mouse pancreas (to simulate an orthotopic pancreatic tumor model) was measured using lithium fluoride thermoluminescent dosimeters. Ultrafast micro-CT was performed using 80 kVp, 0.26 mA, 0.156 mm slice thickness, 256 slices, 0.7 mm Al filtration, and 60-second image acquisition time (15 mA second). Micro-CT imaging acquisitions were repeated four times.Results: We measured consistently low tumor doses (0.014 to 0.02 Gy; average = 0.017 Gy) per scan. Orthotopic doses in the region of the pancreas were also consistently low (0.014 to 0.018 Gy; average = 0.016 Gy) per scan.Conclusions: Radiation doses delivered during ultrafast micro-CT serial imaging in the mouse are low and are likely below the threshold to affect tumor growth.