hemoglobin and the Risk of Cerebral infarction: The Framinglam Study
hemoglobin and the Risk of Cerebral infarction: The Framinglam Study
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DOI：
10.1161/01.str.3.4.409
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发表时间：
1972-07-01
期刊：
影响因子：
8.3
通讯作者：
McNamara, Patricia
中科院分区：
文献类型：
--
作者：
Kannel, William B.;Gordon, Tavia;McNamara, Patricia
根据血红蛋白、血压和吸烟习惯对5,185名男性和女性进行分类，确定了16年以上脑梗死的风险。在血红蛋白值的正常范围内，发现男女的风险与血液血红蛋白浓度成正比。血红蛋白值为15克或更高的男性和14克或更高的女性患脑梗死的人数是血红蛋白值较低的同龄人的两倍。82例脑梗死的初始发病风险与男女患者的血压状况和吸烟也有显著的相关性当考虑到与血液血红蛋白值和脑梗死发病率相关的血压和吸烟习惯因素时，血红蛋白水平仅具有适度的残余效应，不再具有统计学显著性。血液血红蛋白相互关系的发病、预防和治疗意义，血压和吸烟习惯及其与脑梗塞的关系需要进一步研究。
Risk of cerebral infarction over 16 years was ascertained in 5,185 men and women classified according to their hemoglobin, blood pressure and cigarette habit on entry to the Framingham Study. Within the normal range of hemoglobin values, risk was found to be proportional to the blood hemoglobin concentration in both sexes.Men with hemoglobin values of 15 gm or greater and women with 14 gm or more had twice as many cerebral infarctions as did their cohorts with lower values, The risk of initial development of 82 cerebral infarctions was also strikingly related to antecedent blood pressure status in both sexes and to the cigarette habit in men, When allowance is made for associated blood pressure and cigarette habit factors found to correlate with both blood hemoglobin values and incidence of cerebral infarction hemoglobin level had only a modest residual effect, no longer statistically significant,The pathogenetic, preventive and therapeutic implications of the interrelationship of blood hemoglobin, blood pressure and the cigarette habit and their association with cerebral infarction require further exploration.