EnsInfer: a simple ensemble approach to network inference outperforms any single method.
EnsInfer: a simple ensemble approach to network inference outperforms any single method.
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DOI:
10.1186/s12859-023-05231-1
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发表时间:
2023-03-24
影响因子:
3
通讯作者:
中科院分区:
文献类型:
--
作者:
This study evaluates both a variety of existing base causal inference methods and a variety of ensemble methods. We show that: (i) base network inference methods vary in their performance across different datasets, so a method that works poorly on one dataset may work well on another; (ii) a non-homogeneous ensemble method in the form of a Naive Bayes classifier leads overall to as good or better results than using the best single base method or any other ensemble method; (iii) for the best results, the ensemble method should integrate all methods that satisfy a statistical test of normality on training data. The resulting ensemble model EnsInfer easily integrates all kinds of RNA-seq data as well as new and existing inference methods. The paper categorizes and reviews state-of-the-art underlying methods, describes the EnsInfer ensemble approach in detail, and presents experimental results. The source code and data used will be made available to the community upon publication. The online version contains supplementary material available at 10.1186/s12859-023-05231-1.
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影响因子:
9.9
作者:
Arrieta-Ortiz ML;Hafemeister C;Bate AR;Chu T;Greenfield A;Shuster B;Barry SN;Gallitto M;Liu B;Kacmarczyk T;Santoriello F;Chen J;Rodrigues CD;Sato T;Rudner DZ;Driks A;Bonneau R;Eichenberger P
通讯作者:
Eichenberger P
影响因子:
48
作者:
Hill SM;Heiser LM;Cokelaer T;Unger M;Nesser NK;Carlin DE;Zhang Y;Sokolov A;Paull EO;Wong CK;Graim K;Bivol A;Wang H;Zhu F;Afsari B;Danilova LV;Favorov AV;Lee WS;Taylor D;Hu CW;Long BL;Noren DP;Bisberg AJ;HPN-DREAM Consortium;Mills GB;Gray JW;Kellen M;Norman T;Friend S;Qutub AA;Fertig EJ;Guan Y;Song M;Stuart JM;Spellman PT;Koeppl H;Stolovitzky G;Saez-Rodriguez J;Mukherjee S
通讯作者:
Mukherjee S
影响因子:
16.6
作者:
Hayashi T;Ozaki H;Sasagawa Y;Umeda M;Danno H;Nikaido I
通讯作者:
Nikaido I
DOI:
10.1016/j.techfore.2021.120796
发表时间:
2021-05-11
影响因子:
12
作者:
Shahabadi, Mohammad Saleh Ebrahimi;Tabrizchi, Hamed;Palmieri, Francesco
通讯作者:
Palmieri, Francesco
影响因子:
48
作者:
Marbach, Daniel;Costello, James C.;Kueffner, Robert;Vega, Nicole M.;Prill, Robert J.;Camacho, Diogo M.;Allison, Kyle R.;Kellis, Manolis;Collins, James J.;Stolovitzky, Gustavo
通讯作者:
Stolovitzky, Gustavo