Circulating angiotensin II mediates sodium appetite in adrenalectomized rats.
Circulating angiotensin II mediates sodium appetite in adrenalectomized rats.
复制标题
DOI：
10.1152/ajpregu.2001.281.3.r723
复制
发表时间：
2001-09
期刊：
影响因子：
--
通讯作者：
G. Schoorlemmer;A. K. Johnson;R. Thunhorst
中科院分区：
文献类型：
--
作者：
G. Schoorlemmer;A. K. Johnson;R. Thunhorst
我们研究了肾上腺切除术后循环 ANG II 在钠食欲中的作用。肾上腺切除的大鼠被剥夺主要接触钠（0.3 M NaCl）9小时，在2小时内饮用14.1+/-1.5ml浓缩盐水溶液。在限钠的最后 5 小时内静脉输注卡托普利 (2.5 mg/h) 可将钠摄入量减少 77 +/- 12% (n = 5)，而不影响钠消耗和剥夺期间发生的血容量不足的程度。功能证据表明，该剂量的卡托普利可阻止外周循环中 ANG II 的产生，但不会阻止大脑中的 ANG II 产生。也就是说，将 ANG I 注射到侧脑室会刺激水和 0.3 M NaCl 的摄入。在肾上腺切除、卡托普利治疗的大鼠中静脉输注 ANG II（在 0.3 M 氯化钠可用之前 10-15 分钟开始）将钠摄入量和血压恢复到未用卡托普利治疗的大鼠中观察到的值。在 22 小时限钠大鼠中较长时间（20 小时）输注卡托普利也能抑制钠食欲，但减少或防止钠消耗。在这些长时间输注卡托普利后静脉输注 ANG II 刺激了钠摄入量，但摄入量低于未用卡托普利治疗的对照组。这些结果表明，肾上腺切除大鼠的大部分或全部钠食欲是由循环ANG II介导的。
We investigated the role of circulating ANG II in sodium appetite after adrenalectomy. Adrenalectomized rats deprived of their main access to sodium (0.3 M NaCl) for 9 h drank 14.1 +/- 1.5 ml of the concentrated saline solution in 2 h of access. Intravenous infusion of captopril (2.5 mg/h) during the last 5 h of sodium restriction reduced sodium intake by 77 +/- 12% (n = 5) without affecting the degree of sodium depletion and hypovolemia incurred during deprivation. Functional evidence indicates that this dose of captopril blocked production of ANG II in the peripheral circulation, but not in the brain; that is, injection of ANG I into the lateral brain ventricle stimulated intake of both water and 0.3 M NaCl. Intravenous infusion of ANG II (starting 10-15 min before 0.3 M NaCl became available) in adrenalectomized, captopril-treated rats restored both sodium intake and blood pressure to values seen in rats not treated with captopril. Longer (20 h) infusions of captopril in 22-h sodium-restricted rats also blocked sodium appetite, but reduced or prevented sodium depletion. Intravenous infusion of ANG II after these long captopril infusions stimulated sodium intake, but intake was less than in controls not treated with captopril. These results indicate that most or all of the sodium appetite of adrenalectomized rats is mediated by circulating ANG II.