Prognostic significance of natural killer cell activity in patients with laryngeal carcinoma.
Prognostic significance of natural killer cell activity in patients with laryngeal carcinoma.
复制标题
自然杀伤细胞活性对喉癌患者的预后意义。
DOI：
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复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
MS Alberto Dura´ntez
中科院分区：
文献类型：
--
作者：
MD Francisco M. Gonza´lez;PhD Juan A. Vargas;PhD Cristo´bal Lo´pez;PhD Raquel Castejo´n Md;BSc Carmen Gorriz;MD Rafael Ramı´rez;PhD Isabel Milla´n Md;MS Alberto Dura´ntez
背景
BACKGROUND
For laryngeal carcinoma, the present TNM clinical staging system does not seem completely satisfactory as a guide for providing a prognosis for survival. We believe that natural killer cell activity would probably have a role in a more reliable system. Therefore, we analyzed the disease outcome with previously untreated epidermoid carcinoma of the larynx, evaluating classic clinical and pathologic factors, as well as natural killer cell activity in peripheral blood samples of the patients.
OBJECTIVES
To determine the level of natural killer cell activity in patients with laryngeal carcinoma and to analyze the prognostic value of this finding when associated with other clinical and pathologic variables.
DESIGN
Prospective cohort study of surveillance of laryngeal cancer. Mean follow-up of 42.8 months.
SETTINGS
Tertiary care referral center and ambulatory and hospitalized care.
PARTICIPANTS
We compared 81 men (mean age, 62.4 years; range, 35-89 years) with laryngeal carcinoma with 44 healthy men serving as control subjects (mean age, 57.6 years; range, 37-82 years).
RESULTS
Natural killer cell activity was significantly reduced in patients who had died of cancer-related causes in comparison with tumor-free survivors. Overall actuarial survival differed significantly in histologically assessed nodal involvement and low natural killer cell activity. Use of the Cox proportional hazards regression model showed that the factors that seem to have a prognostic effect on survival are histologically determined nodal involvement and low natural killer cell activity.
CONCLUSIONS
These results support the prognostic significance of the determination of pretreatment natural killer cell activity in peripheral blood samples from patients with laryngeal carcinoma and suggest that assessment of adding such a determination to the current tumor staging system is advisable.
具有高家族癌症发病率的个体外周血单核细胞的自然细胞毒性较低。
影响因子：
11.2
作者：
Strayer,DR;Carter,WA;Mayberry,SD;Pequignot,E;Brodsky,I
通讯作者：
Brodsky,I
影响因子：
3
作者：
Stimson P. Schantz;Howard E. Savage;Tamas Racz;D. Taylor;Peter G. Sacks
通讯作者：
Stimson P. Schantz;Howard E. Savage;Tamas Racz;D. Taylor;Peter G. Sacks