INCLUSION COMPLEXATION OF DOXORUBICIN AND DAUNORUBICIN WITH CYCLODEXTRINS
INCLUSION COMPLEXATION OF DOXORUBICIN AND DAUNORUBICIN WITH CYCLODEXTRINS
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DOI：
10.1016/0731-7085(90)80100-4
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发表时间：
1990-01-01
影响因子：
3.4
通讯作者：
UNDERBERG, WJM
中科院分区：
文献类型：
--
作者：
BEKERS, O;BEIJNEN, JH;UNDERBERG, WJM
用液相色谱、圆二色谱和吸收光谱研究了α-、β-和γ-环糊精与蒽环类抗生素阿霉素和柔红霉素的相互作用。 所有研究均在不同温度和pH值的水性介质中进行。 蒽环类药物仅与γ-环糊精复合。 采用Lineweaver-Burk和Scott's作图法计算了蒽环类药物-γ-环糊精包合物的稳定常数。
The interaction of alpha-, beta- and gamma-cyclodextrins with the anthracycline antibiotics doxorubicin and daunorubicin was investigated by LC, circular dichroism (CD) and absorption spectroscopy. All studies were performed in aqueous media at different temperatures and pH values. The anthracyclines complex only with gamma-cyclodextrin. Lineweaver-Burk and Scott's plots were used to calculate the stability constants of the anthracycline-gamma-cyclodextrin inclusion complexes.