Impact of Site-Specific Metastases on Surgical Value and Survival among Metastatic Colorectal Cancer Patients
Impact of Site-Specific Metastases on Surgical Value and Survival among Metastatic Colorectal Cancer Patients
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特定部位转移对转移性结直肠癌患者手术价值和生存的影响
DOI：
10.1177/000313482008600331
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发表时间：
2020-03
期刊：
影响因子：
1
通讯作者：
Yi Cheng-Hao
中科院分区：
文献类型：
--
作者：
Zong Zhen;Zhou Tai-Cheng;Tang Fu-Xin;Tian Hua-Kai;Wang Anan;Yi Cheng-Hao
我们的目的是探讨转移部位对IV期结直肠癌伴同步转移患者的治疗方法和预后的潜在预后影响。本研究纳入了2010年至2013年期间向监测、流行病学和最终结果计划数据库报告的同步转移性结直肠癌患者。使用风险调整的考克斯比例风险回归模型比较了不同治疗方案的患者之间的总生存期（OS）。总的来说，确定了17，776例IV期结直肠癌患者。在这些患者中，2，052例（11.5%）在原发和转移部位接受了肿瘤手术切除。与接受非手术治疗的患者相比，手术切除原发灶和转移灶（肝、肺和同时发生肝和肺转移）的患者的中位OS更长（P < 0.001）。考克斯回归分析显示，原发灶和转移灶同时切除与OS显著增加相关（P < 0.001）。结直肠癌肝或肺转移患者，谁接受了直肠切除术，即使在选定的患者肝和肺转移后，多学科评估，可以有一个更好的生存效益比患者接受非手术治疗。
We aimed to explore the potential prognostic impact of the metastatic site on the management approach and prognosis of stage IV colorectal cancer patients with synchronous metastases. Synchronous metastatic colorectal cancer patients reported to the Surveillance, Epidemiology, and End Results Program database between 2010 and 2013 were included in this study. Overall survival (OS) was compared between patients with different treatment options using risk-adjusted Cox proportional hazard regression models. Overall, 17,776 patients with stage IV colorectal cancer were identified. Of these patients, 2,052 (11.5%) underwent surgical resection for tumors at both the primary and meta-static sites. Patients who underwent surgical resection of both primary and metastatic sites with liver, lung, and simultaneous liver and lung metastases had a longer median OS (P < 0.001) than patients who underwent nonsurgical treatments. Cox regression analysis revealed that surgical resection of both primary and metastatic sites was associated with a significantly enhanced OS (P < 0.001). Colorectal cancer patients with hepatic or pulmonary metastases, who underwent metastasectomy, even in selected patients with both hepatic and pulmonary metastases after multidisciplinary evaluation, could have a better survival benefit than patients who underwent nonsurgical treatments.
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原发肿瘤切除与 IV 期结直肠癌生存率提高相关：工具变量分析
影响因子：
4.6
作者：
Xu H;Xia Z;Jia X;Chen K;Li D;Dai Y;Tao M;Mao Y
通讯作者：
Mao Y
DOI：
--
发表时间：
1989-08
期刊：
Cancer metastasis reviews
影响因子：
--
作者：
S. Paget
通讯作者：
S. Paget
影响因子：
2.8
作者：
Schuele, Silke;Dittmar, Yves;Altendorf-Hofmann, Annelore
通讯作者：
Altendorf-Hofmann, Annelore
影响因子：
--
作者：
Tarin, David
通讯作者：
Tarin, David
影响因子：
3.2
作者：
A. Parikh;Shenghua Ni;T. Koyama;T. Pawlik;D. Penson
通讯作者：
A. Parikh;Shenghua Ni;T. Koyama;T. Pawlik;D. Penson