Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).
Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).
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DOI：
10.1007/s10461-015-1082-2
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发表时间：
2016-07
影响因子：
4.4
通讯作者：
iPrEx Study Team
中科院分区：
文献类型：
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作者：
Defechereux PA;Mehrotra M;Liu AY;McMahan VM;Glidden DV;Mayer KH;Vargas L;Amico KR;Chodacki P;Fernandez T;Avelino-Silva VI;Burns D;Grant RM;iPrEx Study Team
我们对iPrEx中的抑郁症进行了纵向和横断面分析，iPrEx是一项在男性和与男性发生性关系的跨性别女性中进行的每日口服FTC/TDF HIV暴露前预防（PrEP）的随机安慰剂对照试验。抑郁相关不良事件（AE）是最常报告的重度或危及生命的AE，与随机分配至FTC/TDF组无关（分别为152 vs. 144 OR 0.66 95% CI 0.35-1.25）。流行病学研究中心抑郁量表（CES-D）和四个问题的自杀意念量表评分在各组之间没有差异。报告首次肛交时发生强迫性行为的参与者的CES-D评分较高（系数：3.23; 95% CI 1.24-5.23），更可能有自杀意念（OR 2.2; 95% CI 1.09-4.26）。在报告非安全套接受性肛交（ncRAI）的人群中，CES-D评分较高（OR 1.46; 95% CI 1.09-1.94）。我们建议在抑郁症期间继续PrEP，并提供心理健康服务。
We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35–1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24–5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09–4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09–1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services.