Post-polymerization crosstalk between the actin cytoskeleton and microtubule network.
Post-polymerization crosstalk between the actin cytoskeleton and microtubule network.
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DOI：
10.1080/19490992.2016.1171428
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发表时间：
2016-05-03
期刊：
影响因子：
--
通讯作者：
Yamada, Kenneth M
中科院分区：
文献类型：
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作者：
Joo, E Emily;Yamada, Kenneth M
细胞骨架系统通过控制细胞的形状、分裂和迁移，在生物体中发挥着许多关键作用，并最终控制动物的形态、生理和功能。虽然细胞骨架系统是不同的，并发挥不同的作用，有越来越多的证据表明，这些不同的细胞骨架系统协调彼此的功能。细胞骨架系统之间的这种协调，通常被称为细胞骨架串扰，已经确定当一个单独的系统的动态状态影响其他系统。在这篇综述中，我们简要地描述了一些行之有效的例子，细胞骨架系统之间的串扰，然后介绍一种新发现的形式的肌动蛋白细胞骨架和微管网络之间的串扰，似乎并不直接改变聚合或解聚的系统。肌动蛋白和微管之间的聚合后串扰的生物学影响和可能的意义将被详细讨论。
Cellular cytoskeletal systems play many pivotal roles in living organisms by controlling cell shape, division, and migration, which ultimately govern morphology, physiology, and functions of animals. Although the cytoskeletal systems are distinct and play different roles, there is growing evidence that these diverse cytoskeletal systems coordinate their functions with each other. This coordination between cytoskeletal systems, often termed cytoskeletal crosstalk, has been identified when the dynamic state of one individual system affects the other system. In this review, we briefly describe some well-established examples of crosstalk between cytoskeletal systems and then introduce a newly discovered form of crosstalk between the actin cytoskeleton and microtubule network that does not appear to directly alter polymerization or depolymerization of either system. The biological impact and possible significance of this post-polymerization crosstalk between actin and microtubules will be discussed in detail.