Present trends in vitamin E research
Present trends in vitamin E research
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DOI：
10.1002/biof.75
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发表时间：
2010-01-01
期刊：
影响因子：
6
通讯作者：
Azzi, Angelo
中科院分区：
文献类型：
--
作者：
Golli, Francesco;Azzi, Angelo
经过近世纪的研究和成千上万的出版物，维生素E的生理功能仍然不清楚。现有证据表明，通过调节特定信号通路和参与增殖、代谢、炎症和抗氧化通路的基因，在细胞稳态中发挥作用。维生素E在人体中的存在受到密切的代谢控制，使得仅α-生育酚和较低程度的γ-生育酚被保留并递送至组织。未大量保留在体内的其他维生素E形式在体外表现出与α-生育酚和细胞特异性毒性和细胞凋亡不同的反应。这些反应可能包括维生素E在疾病预防和治疗中的肿瘤潜在用途。这些次要形式本身或经代谢修饰产生生物活性代谢物的治疗潜力。这些细胞效应超出了归因于V的亲脂性抗氧化剂的性质。特别研究了生育酚在动脉粥样硬化或其他氧化应激条件下的所谓保护作用。了解维生素E的信号传导和基因表达效应可以帮助分配这种维生素的生理作用，这将在本文中讨论。除了维生素E信号传导外，还将关注生育三烯酚作为维生素E研究的新兴主题之一，并将与（C）2010年国际生物化学和分子生物学联合会一起对最新的临床试验进行严格的重新审查。
Nearly after one century of research and thousands of publications, the physiological function(s) of vitamin E remain unclear. Available evidence suggests a role in cell homeostasis that occurs through the modulation of specific signaling pathways and genes involved in proliferative, metabolic, inflammatory, and antioxidant pathways. Vitamin E presence in the human body is under close metabolic control so that only alpha-tocopherol and, to a lower extent, gamma-tocopherol are retained and delivered to tissues. Other vitamin E forms that are not retained in the body in significant amounts, exhibit responses in vitro that are different form those of alpha-tocopherol and cell specific toxicity and apoptosis. These responses provide may include tumor potential use of vitamin E in disease prevention and therapy. a therapeutic potential for these minor forms, either as such or metabolically modified, to produce bioactive metabolites. These cellular effects go beyond the properties of lipophilic antioxidant attributed to v.-tocopherol particularly investigated for its alleged protective role in atherosclerosis or other oxidative stress conditions. Understanding signaling and gene expression effects of vitamin E could help assign a physiological role to this vitamin, which will be discussed in this review. Besides vitamin E signaling, attention will be given to tocotrienols as one of the emerging topics in vitamin E research and a critical re-examination of the most recent clinical trials will be provided together with the (C) 2010 International Union of Biochemistry and Molecular Biology, Inc.