The HLA Polymorphism and Susceptibility to Disease 1
The HLA Polymorphism and Susceptibility to Disease 1
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HLA多态性与疾病易感性1
DOI：
10.1111/j.1423-0410.1976.tb02206.x
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发表时间：
1976
期刊：
影响因子：
2.7
通讯作者：
K. Mittal
中科院分区：
文献类型：
--
作者：
K. Mittal
抽象的。当比较 1,465 名健康白人和 128 名健康黑人个体的 25 种不同 HLA 抗原的遗传分布时，观察到显着差异。白种人的 A1、A3、B8 和 Bw16 的频率明显更高，黑人的 A28 和 Aw30 的频率明显更高。在白种人中发生率最高且正连锁不平衡最大的单倍型是 A1-B8，在黑人中是 A2-B12。两个种族之间的遗传距离为0.0592。
Abstract. Remarkable differences were observed when 1,465 healthy Caucasian individuals and 128 healthy Negro individuals were compared for the genetic distribution of 25 different HLA antigens. Caucasians had a significantly higher frequency of A1, A3, B8, and Bw16, and Negroes of A28 and Aw30. The haplotype which had the highest incidence as well as the greatest positive linkage disequilibrium was A1‐B8 among Caucasians and A2‐B12 among Negroes. Genetic distance between the two races was 0.0592.