INCREASED BACTERIAL BINDING TO RESPIRATORY EPITHELIAL-CELLS IN VITAMIN-A-DEFICIENCY
INCREASED BACTERIAL BINDING TO RESPIRATORY EPITHELIAL-CELLS IN VITAMIN-A-DEFICIENCY
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DOI：
10.1136/bmj.297.6652.834
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发表时间：
1988-10-01
影响因子：
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通讯作者：
CHANDRA, RK
中科院分区：
文献类型：
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作者：
CHANDRA, RK
营养不良是感染的一个重要危险因素。“维生素A缺乏症在经济贫困人口中很常见，包括工业化国家的人口。它与感染（尤其是呼吸道疾病）的高发病率有关，并对儿童发病率和死亡率有很大影响。2所有蛋白质和能量营养不良患者中有30-75%会发生这种情况，并增加了总体死亡风险。维生素A在调节免疫能力方面具有重要作用3：在维生素A缺乏症患者和缺乏维生素A的实验室动物中观察到免疫反应受损。对维生素A缺乏时上皮细胞的屏障功能知之甚少。细菌在系统性侵入开始之前必须粘附在粘膜细胞上。在形态和营业额的变化，
Malnutrition is an important risk factor for infection.'Vitamin A deficiency is common in economically deprived populations, including those in industrialised countries. It is associated with a high incidence of infection, particularly respiratory disease, and contri-butes considerably to childhood morbidity and mortality. 2 It occurs in 30-75% of all patients with protein and energy malnutrition and enhances the overall risk of death. Vitamin A has an important role in regulating immunocompetence3: impaired immune responses were observed in people with vitamin A deficiency as well as in deprived laboratory animals. Little is known about the barrier function of epithelial cells in vitamin A deficiency. Bacteria must adhere to mucosal cells before systemic invasion begins. The alterations in the morphology and turnover of