TRIGEMINAL-BARORECEPTOR REFLEX INTERACTIONS MODULATE HUMAN CARDIAC VAGAL EFFERENT ACTIVITY
TRIGEMINAL-BARORECEPTOR REFLEX INTERACTIONS MODULATE HUMAN CARDIAC VAGAL EFFERENT ACTIVITY
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DOI：
10.1113/jphysiol.1984.sp015054
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发表时间：
1984-01-01
影响因子：
5.5
通讯作者：
RACZKOWSKA, M
中科院分区：
文献类型：
--
作者：
ECKBERG, DL;MOHANTY, SK;RACZKOWSKA, M
迷走神经心脏抑制的瞬时水平反映了迷走神经运动核对多种感觉神经输入的综合反应。研究了来自三叉神经皮肤受体和颈动脉压力感受器的其中两种输入如何相互作用影响人类迷走神经心脏流出。九名健康的年轻人自愿将呼吸频率和潮气量维持在狭窄的范围内。通过短暂的适度颈部抽吸来刺激颈动脉压力感受器。研究中，志愿者俯卧，通过通气管呼吸，在脸部浸入冷水之前和期间，以及静脉注射极低剂量的硫酸阿托品（可增加狗迷走神经心脏传出活动）之前和之后。面部浸泡使血压略有升高，心跳周期延长，压力反射性心动过缓和呼吸性窦性心律失常明显加重。低剂量阿托品结合面部浸泡进一步增加血压、心率、压力反射反应和窦性心律失常。显然，中枢神经系统的 1 个输入（来自三叉神经皮肤受体）会增加迷走神经心脏流出量，增强迷走神经对另一个输入（来自动脉压力感受器）的反应。由于这两种输入的初始路径在解剖学上是分开的，因此呼吸和低剂量阿托品对迷走神经运动核的影响可能从初级三叉神经和压力感受器传入纤维的末端向下游施加。
Instantaneous levels of vagal cardiac inhibition reflect integrated responses of vagal motonuclei to multiple sensory neural inputs. How 2 of these inputs, from trigeminal cutaneous receptors and carotid arterial baroreceptors interact to influence human vagal cardiac outflow, was studied. Nine healthy young men voluntarily maintained breathing rates and tidal volumes within narrow limits. Carotid baroreceptors were stimulated with brief periods of moderate neck suction. Volunteers were studied prone, breathing through a snorkel, before and during face immersion in cold water, and before and after an intravenous injection of a very low dose of atropine sulfate (which increases vagal cardiac efferent activity in dogs). Face immersion raised blood pressure slightly, increased heart period, and augmented baroreflex bradycardia and respiratory sinus arrhythmia significantly. Low-dose atropine together with face immersion further augmented blood pressure, heart period, baroreflex responses and sinus arrhythmia. Evidently, 1 input to the CNS (from trigeminal cutaneous receptors) which increases vagal cardiac outflow, augments vagal responses to another input (from arterial baroreceptors). Since the initial pathways of these 2 inputs are anatomically separate, the influences of respiration and low doses of atropine on vagal motonuclei may be exerted down-stream from the termination of primary trigeminal and baroreceptor afferent fibers.