Evidence of a quantitative trait locus for energy and macronutrient intakes on chromosome 3q27.3:: the Quebec Family Study
Evidence of a quantitative trait locus for energy and macronutrient intakes on chromosome 3q27.3:: the Quebec Family Study
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DOI：
10.1093/ajcn/88.4.1142
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发表时间：
2008-10-01
影响因子：
7.1
通讯作者：
Perusse, Louis
中科院分区：
文献类型：
--
作者：
Choquette, Anne C.;Lemieux, Simone;Perusse, Louis
背景资料：关于影响膳食能量和营养素摄入量的基因知之甚少，尽管有证据表明这些摄入量受遗传因素的影响。目的：我们旨在通过全基因组连锁分析来确定携带影响能量和大量营养素摄入量的基因的染色体区域。设计：采用3-d膳食记录法对来自217个家庭的836名受试者的能量、碳水化合物、脂质和蛋白质摄入量进行了评估。共有443个标记进行了基因分型和连锁测试;年龄和性别调整的能量和常量营养素摄入量表示为克和总能量摄入量的百分比。基于回归（Haseman-Elston）和方差分量（MERLIN）的方法被用来测试与饮食数据的联系。结果：217个核心家系共454对同胞对的基因组扫描结果显示，该家系的遗传多样性与家系的遗传多样性有关（P
Background: Little is known about the genes influencing dietary energy and nutrient intakes, despite evidence that these intakes are influenced by genetic factors.Objective: We aimed to identify, by using a genome- wide linkage analysis, chromosomal regions harboring genes that affect energy and macronutrient intakes.Design: Energy, carbohydrate, lipid, and protein intakes were assessed in 836 subjects from 217 families by using a 3-d dietary record. A total of 443 markers were genotyped and tested for linkage; age- and sex-adjusted energy and macronutrient intakes were expressed in grams and as percentages of total energy intake. Regression-based (Haseman-Elston) and variance-component (MERLIN) methods were applied to test for linkage with dietary data. A maximum of 454 sibpairs from 217 nuclear families were available for analysis.Results: The genome scan provided suggestive evidence (P