Bright light therapy: Improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods
Bright light therapy: Improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods
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DOI：
10.3109/07420529908998724
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发表时间：
1999-01-01
影响因子：
2.8
通讯作者：
Rosenquist, PB
中科院分区：
文献类型：
--
作者：
Van Someren, EJW;Swaab, DF;Rosenquist, PB
阿尔茨海默病（AD）患者的睡眠-觉醒节律紊乱对护理人员提出了强烈的要求，并且是机构化的最重要原因之一。先前的几项研究报告说，随着环境光的增加，干扰得到改善，环境光通过视网膜下丘脑束激活视交叉上核（SCN），大脑的生物钟。使用几种统计程序重新分析了最近发表的关于明亮战斗对痴呆老年人活动评估的休息-活动节律影响的正面和负面报告的数据。结果表明，光诱导的改善耦合的休息-活动节律的环境授时因子的明亮的光是更好地检测使用非参数程序。余弦、复解调和Lomb-Scargle周期图衍生变量对这种效应的敏感性要低得多，因为静息-活动节律的波形高度非正弦。指导方针的活动数据分析，以提高敏感性的治疗效果在未来的研究。
Sleep-wake rhythm disturbances in patients with Alzheimer's disease (AD) make a strong demand on caregivers and are among the most important reasons for institutionalization. Several previous studies reported that the disturbances improve with increased environmental Light, which, through the retinohypothalamic tract, activates the suprachiasmatic nucleus (SCN), the biological clock of the brain. The data of recently published positive and negative reports on the effect of bright Fight on actigraphically assessed rest-activity rhythms in demented elderly were reanalyzed using several statistical procedures. It was demonstrated that the light-induced improvement in coupling of the rest-activity rhythm to the environmental zeitgeber of bright light is better detected using nonparametric procedures. Cosinor, complex demodulation, and Lomb-Scargle periodogram-derived variables are much less sensitive to this effect because of the highly nonsinusoidal waveform of the rest-activity rhythm. Guidelines for analyses of actigraphic data are given to improve the sensitivity to treatment effects in future studies.