Lipid metabolism emerges as a promising target for malignant glioma therapy.
Lipid metabolism emerges as a promising target for malignant glioma therapy.
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DOI：
10.2217/cns.13.20
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Chakravarti A
中科院分区：
文献类型：
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作者：
Guo D;Bell EH;Chakravarti A
恶性胶质瘤是最难治疗的癌症之一。对化疗和放疗的耐药性的发展有助于这些肿瘤的侵袭性表型。在过去的50年里，有关于胶质瘤中脂质水平升高的报道。然而，肿瘤组织如何获得脂质并利用它们的分子机制尚不清楚。最近，肿瘤信号通路EGFR/PI3K/Akt通路已被证明通过上调主要转录因子SREBP-1来控制脂质代谢，从而促进脂质合成和摄取。本文讨论了不同研究组对胶质瘤组织中脂质成分的分析化学结果。本文将讨论癌基因与脂质编程的分子机制，以及抑制恶性胶质瘤脂质代谢的关键分子靶点的鉴定和有效药物的开发。
Malignant gliomas are one of the most treatment-refractory cancers. Development of resistance to chemo- and radio-therapies contributes to these tumors’ aggressive phenotypes. Elevated lipid levels in gliomas have been reported for the last 50 years. However, the molecular mechanisms of how tumor tissues obtain lipids and utilize them are not well understood. Recently, the oncogenic signaling EGFR/PI3K/Akt pathway has been shown to enhance lipid synthesis and uptake by upregulating SREBP-1, a master transcriptional factor, to control lipid metabolism. This article discusses the analytical chemistry results of lipid components in glioma tissues from different research groups. The molecular mechanisms that link oncogenes with lipid programming, and identification of the key molecular targets and development of effective drugs to inhibit lipid metabolism in malignant gliomas will be discussed.